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2017 ; 8
(ä): 278
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
The Immune Epitope Database and Analysis Resource in Epitope Discovery and
Synthetic Vaccine Design
#MMPMID28352270
Fleri W
; Paul S
; Dhanda SK
; Mahajan S
; Xu X
; Peters B
; Sette A
Front Immunol
2017[]; 8
(ä): 278
PMID28352270
show ga
The task of epitope discovery and vaccine design is increasingly reliant on
bioinformatics analytic tools and access to depositories of curated data relevant
to immune reactions and specific pathogens. The Immune Epitope Database and
Analysis Resource (IEDB) was indeed created to assist biomedical researchers in
the development of new vaccines, diagnostics, and therapeutics. The Analysis
Resource is freely available to all researchers and provides access to a variety
of epitope analysis and prediction tools. The tools include validated and
benchmarked methods to predict MHC class I and class II binding. The predictions
from these tools can be combined with tools predicting antigen processing, TCR
recognition, and B cell epitope prediction. In addition, the resource contains a
variety of secondary analysis tools that allow the researcher to calculate
epitope conservation, population coverage, and other relevant analytic variables.
The researcher involved in vaccine design and epitope discovery will also be
interested in accessing experimental published data, relevant to the specific
indication of interest. The database component of the IEDB contains a vast amount
of experimentally derived epitope data that can be queried through a flexible
user interface. The IEDB is linked to other pathogen-specific and immunological
database resources.