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pmid28154282      Intern+Med 2017 ; 56 (3): 353-6
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  • The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet #MMPMID28154282
  • Shimizu R; Ohwada C; Nagao Y; Togasaki E; Kawajiri C; Muto T; Tsukamoto S; Sakai S; Takeda Y; Mimura N; Takeuchi M; Sakaida E; Iseki T; Nakaseko C
  • Intern Med 2017[Feb]; 56 (3): 353-6 PMID28154282show ga
  • Infections of the central nervous system (CNS) with varicella zoster virus (VZV) is a rare occurrence after allogeneic hematopoietic stem cell transplantation. We herein report a case of VZV meningitis, radiculitis and myelitis that developed 8 months after cord blood transplantation, shortly after the cessation of cyclosporine and low-dose acyclovir. Although treatment with acyclovir did not achieve a satisfactory response, the patient was successfully treated with foscarnet. Our report indicates that VZV infection should be considered in allo-hematopoietic stem cell transplantation (HSCT) patients with CNS symptoms and that foscarnet may be effective for the treatment of acyclovir-resistant VZV infections of the CNS. The development of optimal prophylactic strategies and vaccination schedules may eradicate post-transplant VZV disease.
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