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An Atypical Clinical Course of Anti-MDA5 Antibody-positive Interstitial Lung
Disease in a Patient with Three Deteriorations in 9 years
#MMPMID28154280
Sato Y
; Otsuka K
; Tamai K
; Ono Y
; Hamaguchi Y
; Tomii K
Intern Med
2017[]; 56
(3
): 341-346
PMID28154280
show ga
Anti-MDA5 antibody-positive patients with clinically amyopathic dermatomyositis
(CADM) are at high risk of developing rapidly progressive interstitial lung
disease (ILD), which is associated with a high mortality rate. Approximately half
of the patients with ILD recover; however, the long-term clinical course of these
patients has not been fully reported and is not completely understood. This
report describes the atypical clinical course of an anti-MDA5 antibody-positive
CADM patient who experienced three deteriorations of ILD in 9 years. These
findings indicate that the ILD in anti-MDA5 antibody-positive patients may not
only be rapidly progressive, but may also be chronic and recurrent.
|Antibodies, Anti-Idiotypic/*immunology
[MESH]
|DEAD-box RNA Helicases/immunology
[MESH]
|Dermatomyositis/complications/*immunology
[MESH]
|Humans
[MESH]
|Intercellular Signaling Peptides and Proteins
[MESH]