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10.18632/oncotarget.13172 http://scihub22266oqcxt.onion/10.18632/oncotarget.13172 C5348425!5348425 !27835580     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27835580 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (49 ): 81727-81740 Nephropedia Template TP {{tp|p=27835580 |t=2016. KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer |pdf=|usr=}}{{27835580 }} gab.com Text KY1022, a small molecule destabilizing Ras via targeting the Wnt/ -catenin pathway, inhibits development of metastatic colorectal cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27835580 #FOAvip APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both ?-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeting both the Wnt/?-catenin and Ras pathways could be an ideal therapeutic approach for treating mCRC patients. In this study, we characterized the roles of KY1022, a small molecule that destabilizes both ?-catenin and Ras via targeting the Wnt/?-catenin pathway, in inhibiting the cellular events, including EMT, an initial process of metastasis, and apoptosis. As shown by in vitro and in vivo studies using APCMin/+/K-RasG12DLA2 mice, KY1022 effectively suppressed the development of mCRC at an early stage of tumorigenesis. A small molecular approach degrading both ?-catenin and Ras via inhibition of the Wnt/?-catenin signaling would be an ideal strategy for treatment of mCRC. Twit Text FOAVip KY1022, a small molecule destabilizing Ras via targeting the Wnt/ -catenin pathway, inhibits development of metastatic colorectal cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27835580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27835580 #FOAvip English Wikipedia <ref>{{Cite pmid|27835580 }}</ref> KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer #MMPMID27835580 Cho YH ; Cha PH ; Kaduwal S ; Park JC ; Lee SK ; Yoon JS ; Shin W ; Kim H ; Ro EJ ; Koo KH ; Park KS ; Han G ; Choi KY Oncotarget 2016[Dec]; 7 (49 ): 81727-81740 PMID27835580 show ga APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both ?-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeting both the Wnt/?-catenin and Ras pathways could be an ideal therapeutic approach for treating mCRC patients. In this study, we characterized the roles of KY1022, a small molecule that destabilizes both ?-catenin and Ras via targeting the Wnt/?-catenin pathway, in inhibiting the cellular events, including EMT, an initial process of metastasis, and apoptosis. As shown by in vitro and in vivo studies using APCMin/+/K-RasG12DLA2 mice, KY1022 effectively suppressed the development of mCRC at an early stage of tumorigenesis. A small molecular approach degrading both ?-catenin and Ras via inhibition of the Wnt/?-catenin signaling would be an ideal strategy for treatment of mCRC. |Actin Cytoskeleton/drug effects/metabolism/pathology [MESH] |Adenocarcinoma/*drug therapy/genetics/metabolism/secondary [MESH] |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Apoptosis/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/*drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Colorectal Neoplasms/*drug therapy/genetics/metabolism/pathology [MESH] |Disease Models, Animal [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Genes, APC [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Mutation [MESH] |Neoplasm Invasiveness [MESH] |Protein Stability [MESH] |Proteolysis [MESH] |Proto-Oncogene Proteins p21(ras)/genetics/*metabolism [MESH] |Thiohydantoins/*pharmacology [MESH] |Time Factors [MESH] |Wnt Signaling Pathway/*drug effects [MESH]KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-cat(epmc).pdf DeepDyve Pubget Overpricing