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10.18632/oncotarget.13034 http://scihub22266oqcxt.onion/10.18632/oncotarget.13034 C5348407!5348407 !27821799     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27821799 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (49 ): 81474-81492 Nephropedia Template TP {{tp|p=27821799 |t=2016. TWEAK activation of the non-canonical NF-?B signaling pathway differentially regulates melanoma and prostate cancer cell invasion |pdf=|usr=}}{{27821799 }} gab.com Text TWEAK activation of the non-canonical NF- B signaling pathway differentially regulates melanoma and prostate cancer cell invasion JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27821799 #FOAvip Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that binds with high affinity to a plasma membrane-anchored receptor named Fn14. Both TWEAK and Fn14 expression has been detected in human cancer tissue, and studies have shown that TWEAK/Fn14 signaling can promote either "pro-cancer" or "anti-cancer" cellular effects in vitro, depending on the cancer cell line under investigation. In this study, we engineered murine B16 melanoma cells to secrete high levels of soluble TWEAK and examined their properties. TWEAK production by B16 cells preferentially activated the non-canonical NF-?B signaling pathway and increased the expression of several previously described TWEAK-inducible genes, including Fn14. TWEAK overexpression in B16 cells inhibited both cell growth and invasion in vitro. The TWEAK-mediated reduction in B16 cell invasive capacity was dependent on activation of the non-canonical NF-?B signaling pathway. Finally, we found that this same signaling pathway was also important for TWEAK-stimulated human DU145 prostate cancer cell invasion. Therefore, even though TWEAK:Fn14 binding activates non-canonical NF-?B signaling in both melanoma and prostate cancer cells, this shared cellular response can trigger a very different downstream outcome (inhibition or stimulation of cell invasiveness, respectively). Twit Text FOAVip TWEAK activation of the non-canonical NF- B signaling pathway differentially regulates melanoma and prostate cancer cell invasion ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27821799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27821799 #FOAvip English Wikipedia <ref>{{Cite pmid|27821799 }}</ref> TWEAK activation of the non-canonical NF-?B signaling pathway differentially regulates melanoma and prostate cancer cell invasion #MMPMID27821799 Armstrong CL ; Galisteo R ; Brown SA ; Winkles JA Oncotarget 2016[Dec]; 7 (49 ): 81474-81492 PMID27821799 show ga Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that binds with high affinity to a plasma membrane-anchored receptor named Fn14. Both TWEAK and Fn14 expression has been detected in human cancer tissue, and studies have shown that TWEAK/Fn14 signaling can promote either "pro-cancer" or "anti-cancer" cellular effects in vitro, depending on the cancer cell line under investigation. In this study, we engineered murine B16 melanoma cells to secrete high levels of soluble TWEAK and examined their properties. TWEAK production by B16 cells preferentially activated the non-canonical NF-?B signaling pathway and increased the expression of several previously described TWEAK-inducible genes, including Fn14. TWEAK overexpression in B16 cells inhibited both cell growth and invasion in vitro. The TWEAK-mediated reduction in B16 cell invasive capacity was dependent on activation of the non-canonical NF-?B signaling pathway. Finally, we found that this same signaling pathway was also important for TWEAK-stimulated human DU145 prostate cancer cell invasion. Therefore, even though TWEAK:Fn14 binding activates non-canonical NF-?B signaling in both melanoma and prostate cancer cells, this shared cellular response can trigger a very different downstream outcome (inhibition or stimulation of cell invasiveness, respectively). |*Cell Movement [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Chemokines/genetics/metabolism [MESH] |Cytokine TWEAK/genetics/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Male [MESH] |Melanoma, Experimental/genetics/*metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/*metabolism [MESH] |Neoplasm Invasiveness [MESH] |Prostatic Neoplasms/genetics/*metabolism/pathology [MESH] |RNA Interference [MESH] |Signal Transduction [MESH] |Skin Neoplasms/genetics/*metabolism/pathology [MESH] |TWEAK Receptor/genetics/metabolism [MESH] |Time Factors [MESH]TWEAK activation of the non-canonical NF-?B signaling pathway differen(epmc).pdf DeepDyve Pubget Overpricing