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10.18632/oncotarget.12937 http://scihub22266oqcxt.onion/10.18632/oncotarget.12937 C5348402!5348402 !27806310     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27806310 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (49 ): 81410-81422 Nephropedia Template TP {{tp|p=27806310 |t=2016. Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-?1/p38/HSP27 signaling in renal cell carcinoma |pdf=|usr=}}{{27806310 }} gab.com Text Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF- 1/p38/HSP27 signaling in renal cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27806310 #FOAvip Antisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies. However, the function of lncRNAs and their underlying mechanism in renal cell carcinoma (RCC) is still unknown. The aims of this study are to investigate the expression of lncRNA BX357664 in RCC and to explore its function in RCC cell lines. As a result, BX357664 was downregulated in RCC according to previous microarray analysis and qualitative real-time polymerase chain reaction. After the upregulation of BX357664, reduced migration, invasion, and proliferation capabilities in RCC cells were detected. Furthermore, Western blot analysis was conducted to identify the influence of BX357664 on epithelial-to-mesenchymal transition, matrix metalloproteinase 2, matrix metalloproteinase 9, and transforming growth factor-beta 1 (TGF-?1)/p38/HSP27 signaling pathway in RCC. Subsequently, upregulating the protein level of TGF-?1 in the presence of BX357664 could rescue the suppression of the malignant behavior mediated by BX357664, indicating that BX357664 attributed its inhibitory role to the suppression of TGF-?1. Therefore, we investigated a novel lncRNA BX357664, which might exhibit its inhibitory role in RCC metastasis and progression by blocking the TGF-?1/p38/HSP27 pathway. Twit Text FOAVip Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF- 1/p38/HSP27 signaling in renal cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27806310 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27806310 #FOAvip English Wikipedia <ref>{{Cite pmid|27806310 }}</ref> Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-?1/p38/HSP27 signaling in renal cell carcinoma #MMPMID27806310 Liu Y ; Qian J ; Li X ; Chen W ; Xu A ; Zhao K ; Hua Y ; Huang Z ; Zhang J ; Liang C ; Su S ; Li P ; Shao P ; Li J ; Qin C ; Wang Z Oncotarget 2016[Dec]; 7 (49 ): 81410-81422 PMID27806310 show ga Antisense long noncoding RNAs (lncRNAs) are reported to play a regulating role in carcinogenesis of various human malignancies. However, the function of lncRNAs and their underlying mechanism in renal cell carcinoma (RCC) is still unknown. The aims of this study are to investigate the expression of lncRNA BX357664 in RCC and to explore its function in RCC cell lines. As a result, BX357664 was downregulated in RCC according to previous microarray analysis and qualitative real-time polymerase chain reaction. After the upregulation of BX357664, reduced migration, invasion, and proliferation capabilities in RCC cells were detected. Furthermore, Western blot analysis was conducted to identify the influence of BX357664 on epithelial-to-mesenchymal transition, matrix metalloproteinase 2, matrix metalloproteinase 9, and transforming growth factor-beta 1 (TGF-?1)/p38/HSP27 signaling pathway in RCC. Subsequently, upregulating the protein level of TGF-?1 in the presence of BX357664 could rescue the suppression of the malignant behavior mediated by BX357664, indicating that BX357664 attributed its inhibitory role to the suppression of TGF-?1. Therefore, we investigated a novel lncRNA BX357664, which might exhibit its inhibitory role in RCC metastasis and progression by blocking the TGF-?1/p38/HSP27 pathway. |*Cell Proliferation/drug effects [MESH] |*Epithelial-Mesenchymal Transition/drug effects [MESH] |*Signal Transduction/drug effects [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HEK293 Cells [MESH] |HSP27 Heat-Shock Proteins/*metabolism [MESH] |Heat-Shock Proteins [MESH] |Humans [MESH] |Kidney Neoplasms/genetics/*metabolism/pathology [MESH] |Male [MESH] |Matrix Metalloproteinase 2/metabolism [MESH] |Matrix Metalloproteinase 9/metabolism [MESH] |Middle Aged [MESH] |Molecular Chaperones [MESH] |Neoplasm Invasiveness [MESH] |RNA, Long Noncoding/*genetics/metabolism [MESH] |Time Factors [MESH] |Transfection [MESH] |Transforming Growth Factor beta1/*metabolism/pharmacology [MESH]Long noncoding RNA BX357664 regulates cell proliferation and epithel(epmc).pdf DeepDyve Pubget Overpricing