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10.18632/oncotarget.13061 http://scihub22266oqcxt.onion/10.18632/oncotarget.13061 C5348328!5348328 !27823982     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27823982 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (49 ): 80391-80403 Nephropedia Template TP {{tp|p=27823982 |t=2016. ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells |pdf=|usr=}}{{27823982 }} gab.com Text ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27823982 #FOAvip Established adriamycin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50% in a year. It has been known that ANGPTLs has various functions in lipid metabolism, inflammation, cancer cell invasion, hematopoietic stem activity and diabetes. We hypothesized that ANGPTL8 is capable of maintaining heart function by stimulating adult cardiac progenitor cells to initiate myocardial regeneration. We employed UTMD to deliver piggybac transposon plasmids with the human ANGPTL8 gene to the liver of rats with adriamycin cardiomyopathy. After ANGPTL8 gene liver delivery, overexpression of transgenic human ANGPTL8 was found in rat liver cells and blood. UTMD- ANGPTL8 gene therapy restored LV mass, fractional shortening index, and LV posterior wall diameter to nearly normal. Our results also showed that ANGPTL8 reversed established ADM cardiomyopathy. This was associated with activation of ISL-1 positive cardiac progenitor cells in the epicardium. A time-course experiment shown that ISL-1 cardiac progenitor cells proliferated and formed a niche in the epicardial layer and then migrated into sub-epicardium. The observed myocardial regeneration accompanying reversal of adriamycin cardiomyopathy was associated with upregulation of PirB expression on the cell membrane of cardiac muscle cells or progenitor cells stimulated by ANGPTL8. Twit Text FOAVip ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27823982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27823982 #FOAvip English Wikipedia <ref>{{Cite pmid|27823982 }}</ref> ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells #MMPMID27823982 Chen S ; Chen J ; Meng XL ; Shen JS ; Huang J ; Huang P ; Pu Z ; McNeill NH ; Grayburn PA Oncotarget 2016[Dec]; 7 (49 ): 80391-80403 PMID27823982 show ga Established adriamycin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50% in a year. It has been known that ANGPTLs has various functions in lipid metabolism, inflammation, cancer cell invasion, hematopoietic stem activity and diabetes. We hypothesized that ANGPTL8 is capable of maintaining heart function by stimulating adult cardiac progenitor cells to initiate myocardial regeneration. We employed UTMD to deliver piggybac transposon plasmids with the human ANGPTL8 gene to the liver of rats with adriamycin cardiomyopathy. After ANGPTL8 gene liver delivery, overexpression of transgenic human ANGPTL8 was found in rat liver cells and blood. UTMD- ANGPTL8 gene therapy restored LV mass, fractional shortening index, and LV posterior wall diameter to nearly normal. Our results also showed that ANGPTL8 reversed established ADM cardiomyopathy. This was associated with activation of ISL-1 positive cardiac progenitor cells in the epicardium. A time-course experiment shown that ISL-1 cardiac progenitor cells proliferated and formed a niche in the epicardial layer and then migrated into sub-epicardium. The observed myocardial regeneration accompanying reversal of adriamycin cardiomyopathy was associated with upregulation of PirB expression on the cell membrane of cardiac muscle cells or progenitor cells stimulated by ANGPTL8. |*Doxorubicin [MESH] |Angiopoietin-Like Protein 8 [MESH] |Angiopoietin-like Proteins/*biosynthesis/blood/genetics [MESH] |Animals [MESH] |Cardiomyopathies/chemically induced/genetics/metabolism/*therapy [MESH] |Cardiotoxicity [MESH] |Cell Line [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Disease Models, Animal [MESH] |Gene Transfer Techniques [MESH] |Genetic Therapy/*methods [MESH] |Humans [MESH] |LIM-Homeodomain Proteins/metabolism [MESH] |Liver/*metabolism [MESH] |Male [MESH] |Microbubbles [MESH] |Myocardial Contraction [MESH] |Myocytes, Cardiac/*metabolism/pathology [MESH] |Peptide Hormones/*biosynthesis/blood/genetics [MESH] |Rats, Sprague-Dawley [MESH] |Receptors, Immunologic/metabolism [MESH] |Recovery of Function [MESH] |Regeneration [MESH] |Stem Cell Niche [MESH] |Stem Cells/*metabolism/pathology [MESH] |Time Factors [MESH] |Transcription Factors/metabolism [MESH] |Ultrasonics [MESH] |Ventricular Function, Left [MESH]ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating (epmc).pdf DeepDyve Pubget Overpricing