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Tetrandrine inhibits migration and invasion of human renal cell carcinoma by
regulating Akt/NF-?B/MMP-9 signaling
#MMPMID28288190
Chen S
; Liu W
; Wang K
; Fan Y
; Chen J
; Ma J
; Wang X
; He D
; Zeng J
; Li L
PLoS One
2017[]; 12
(3
): e0173725
PMID28288190
show ga
Renal cell carcinoma (RCC) is known as one of the most lethal malignancies in the
urological system because of its high incidence of metastasis. Tetrandrine (Tet),
a traditional Chinese herbal medicine, exerts a potent anti-cancer effect in a
variety of cancer cells. However, the anti-metastatic effect of Tet and its
possible mechanism in RCC is still unclear. The present study revealed that Tet
significantly suppressed the migration and invasion of RCC 786-O and 769-P cells
in vitro. Mechanistically, the protein levels of matrix metalloproteinases 9
(MMP-9), phosphorylated PI3K, PDK1, Akt and NF-?B were markedly reduced after Tet
treatment. Moreover, co-treatment with LY294002 (PI3K inhibitor) could further
enhance the Tet-inhibited migration and invasion, and the NF-?B and MMP-9 protein
levels were further decreased. Similar results were observed after PDTC (NF-?B
inhibitor) co-treatment. Conversely, SC79, an Akt activator, could partially
reverse the anti-metastatic effects of Tet, accompanied by the restoration of
NF-?B and MMP-9 protein levels. In conclusion, the current results indicated that
Tet inhibited migration and invasion of RCC partially by regulating
Akt/NF-?B/MMP-9 signaling pathway, suggesting that Tet may be a potential
therapeutic candidate against metastatic RCC.
|3-Phosphoinositide-Dependent Protein Kinases/metabolism
[MESH]
free
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