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10.1371/journal.pone.0173725 http://scihub22266oqcxt.onion/10.1371/journal.pone.0173725 C5348026!5348026 !28288190     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28288190 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2017 ; 12 (3 ): e0173725 Nephropedia Template TP {{tp|p=28288190 |t=2017. Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-?B/MMP-9 signaling |pdf=|usr=}}{{28288190 }} gab.com Text Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF- B/MMP-9 signaling JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28288190 #FOAvip Renal cell carcinoma (RCC) is known as one of the most lethal malignancies in the urological system because of its high incidence of metastasis. Tetrandrine (Tet), a traditional Chinese herbal medicine, exerts a potent anti-cancer effect in a variety of cancer cells. However, the anti-metastatic effect of Tet and its possible mechanism in RCC is still unclear. The present study revealed that Tet significantly suppressed the migration and invasion of RCC 786-O and 769-P cells in vitro. Mechanistically, the protein levels of matrix metalloproteinases 9 (MMP-9), phosphorylated PI3K, PDK1, Akt and NF-?B were markedly reduced after Tet treatment. Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-?B and MMP-9 protein levels were further decreased. Similar results were observed after PDTC (NF-?B inhibitor) co-treatment. Conversely, SC79, an Akt activator, could partially reverse the anti-metastatic effects of Tet, accompanied by the restoration of NF-?B and MMP-9 protein levels. In conclusion, the current results indicated that Tet inhibited migration and invasion of RCC partially by regulating Akt/NF-?B/MMP-9 signaling pathway, suggesting that Tet may be a potential therapeutic candidate against metastatic RCC. Twit Text FOAVip Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF- B/MMP-9 signaling ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28288190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28288190 #FOAvip English Wikipedia <ref>{{Cite pmid|28288190 }}</ref> Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-?B/MMP-9 signaling #MMPMID28288190 Chen S ; Liu W ; Wang K ; Fan Y ; Chen J ; Ma J ; Wang X ; He D ; Zeng J ; Li L PLoS One 2017[]; 12 (3 ): e0173725 PMID28288190 show ga Renal cell carcinoma (RCC) is known as one of the most lethal malignancies in the urological system because of its high incidence of metastasis. Tetrandrine (Tet), a traditional Chinese herbal medicine, exerts a potent anti-cancer effect in a variety of cancer cells. However, the anti-metastatic effect of Tet and its possible mechanism in RCC is still unclear. The present study revealed that Tet significantly suppressed the migration and invasion of RCC 786-O and 769-P cells in vitro. Mechanistically, the protein levels of matrix metalloproteinases 9 (MMP-9), phosphorylated PI3K, PDK1, Akt and NF-?B were markedly reduced after Tet treatment. Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-?B and MMP-9 protein levels were further decreased. Similar results were observed after PDTC (NF-?B inhibitor) co-treatment. Conversely, SC79, an Akt activator, could partially reverse the anti-metastatic effects of Tet, accompanied by the restoration of NF-?B and MMP-9 protein levels. In conclusion, the current results indicated that Tet inhibited migration and invasion of RCC partially by regulating Akt/NF-?B/MMP-9 signaling pathway, suggesting that Tet may be a potential therapeutic candidate against metastatic RCC. |3-Phosphoinositide-Dependent Protein Kinases/metabolism [MESH] |Antineoplastic Agents, Phytogenic/pharmacology [MESH] |Benzylisoquinolines/*pharmacology [MESH] |Carcinoma, Renal Cell/*drug therapy/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Humans [MESH] |Kidney Neoplasms/*drug therapy/metabolism/pathology [MESH] |Matrix Metalloproteinase 9/*metabolism [MESH] |NF-kappa B/metabolism [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Phosphorylation/drug effects [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH]Tetrandrine inhibits migration and invasion of human renal cell carcin(epmc).pdf DeepDyve Pubget Overpricing