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10.1002/pmic.201600213 http://scihub22266oqcxt.onion/10.1002/pmic.201600213 C5347865!5347865!28058811     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28058811.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proteomics 2017 ; 17 (5): ä Nephropedia Template TP {{tp|p=28058811|t=2017. Proteomic characterization of microdissected breast tissue environment provides a protein?level overview of malignant transformation |pdf=|usr=}}{{28058811}} gab.com Text Proteomic characterization of microdissected breast tissue environment provides a protein level overview of malignant transformation JO: Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=28058811 #FOAvip Both healthy and cancerous breast tissue is heterogeneous, which is a bottleneck for proteomics?based biomarker analysis, as it obscures the cellular origin of a measured protein. We therefore aimed at obtaining a protein?level interpretation of malignant transformation through global proteome analysis of a variety of laser capture microdissected cells originating from benign and malignant breast tissues. We compared proteomic differences between these tissues, both from cells of epithelial origin and the stromal environment, and performed string analysis. Differences in protein abundances corresponded with several hallmarks of cancer, including loss of cell adhesion, transformation to a migratory phenotype, and enhanced energy metabolism. Furthermore, despite enriching for (tumor) epithelial cells, many changes to the extracellular matrix were detected in microdissected cells of epithelial origin. The stromal compartment was heterogeneous and richer in the number of fibroblast and immune cells in malignant sections, compared to benign tissue sections. Furthermore, stroma could be clearly divided into reactive and nonreactive based on extracellular matrix disassembly proteins. We conclude that proteomics analysis of both microdissected epithelium and stroma gives an additional layer of information and more detailed insight into malignant transformation. Twit Text FOAVip Proteomic characterization of microdissected breast tissue environment provides a protein level overview of malignant transformation ????Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=28058811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28058811 #FOAvip English Wikipedia <ref>{{Cite pmid|28058811}}</ref> Proteomic characterization of microdissected breast tissue environment provides a protein?level overview of malignant transformation #MMPMID28058811 Braakman RBH; Stingl C; Tilanus?Linthorst MMA; van Deurzen CHM; Timmermans MAM; Smid M; Foekens JA; Luider TM; Martens JWM; Umar A Proteomics 2017[Mar]; 17 (5): ä PMID28058811show ga Both healthy and cancerous breast tissue is heterogeneous, which is a bottleneck for proteomics?based biomarker analysis, as it obscures the cellular origin of a measured protein. We therefore aimed at obtaining a protein?level interpretation of malignant transformation through global proteome analysis of a variety of laser capture microdissected cells originating from benign and malignant breast tissues. We compared proteomic differences between these tissues, both from cells of epithelial origin and the stromal environment, and performed string analysis. Differences in protein abundances corresponded with several hallmarks of cancer, including loss of cell adhesion, transformation to a migratory phenotype, and enhanced energy metabolism. Furthermore, despite enriching for (tumor) epithelial cells, many changes to the extracellular matrix were detected in microdissected cells of epithelial origin. The stromal compartment was heterogeneous and richer in the number of fibroblast and immune cells in malignant sections, compared to benign tissue sections. Furthermore, stroma could be clearly divided into reactive and nonreactive based on extracellular matrix disassembly proteins. We conclude that proteomics analysis of both microdissected epithelium and stroma gives an additional layer of information and more detailed insight into malignant transformation. äProteomic characterization of microdissected breast tissue environment(epmc).pdf DeepDyve Pubget Overpricing