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10.18632/oncotarget.13360 http://scihub22266oqcxt.onion/10.18632/oncotarget.13360 C5347798!5347798 !27863411     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27863411 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27863411 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (50 ): 83720-83726 Nephropedia Template TP {{tp|p=27863411 |t=2016. Sesamin inhibits IL-1?-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway |pdf=|usr=}}{{27863411 }} gab.com Text Sesamin inhibits IL-1 -stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863411 #FOAvip Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1?-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1?. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1?-stimulated chondrocytes. Sesamin also inhibited IL-1?-induced phosphorylation of NF-?B p65 and I?B?. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1?-stimulated chondrocytes by activating Nrf2 signaling pathway. Twit Text FOAVip Sesamin inhibits IL-1 -stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27863411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863411 #FOAvip English Wikipedia <ref>{{Cite pmid|27863411 }}</ref> Sesamin inhibits IL-1?-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway #MMPMID27863411 Kong P ; Chen G ; Jiang A ; Wang Y ; Song C ; Zhuang J ; Xi C ; Wang G ; Ji Y ; Yan J Oncotarget 2016[Dec]; 7 (50 ): 83720-83726 PMID27863411 show ga Sesamin, a bioactive component extracted from sesame, has been reported to exert anti-inflammatory and anti-oxidant effects. In this study, we evaluated the anti-inflammatory effects of sesamin on IL-1?-stimulated human osteoarthritis chondrocytes and investigated the possible mechanism. Results demonstrated that sesamin treatment significantly inhibited PGE2 and NO production induced by IL-1?. Sesamin inhibited MMP1, MMP3, and MMP13 production in IL-1?-stimulated chondrocytes. Sesamin also inhibited IL-1?-induced phosphorylation of NF-?B p65 and I?B?. Meanwhile, sesamin was found to up-regulate the expression of Nrf2 and HO-1. However, Nrf2 siRNA reversed the anti-inflammatory effects of sesamin. In conclusion, our results suggested that sesamin showed anti-inflammatory effects in IL-1?-stimulated chondrocytes by activating Nrf2 signaling pathway. |Anti-Inflammatory Agents/*pharmacology [MESH] |Cell Survival/drug effects [MESH] |Cells, Cultured [MESH] |Chondrocytes/*drug effects/immunology/metabolism [MESH] |Dinoprostone/metabolism [MESH] |Dioxoles/*pharmacology [MESH] |Dose-Response Relationship, Drug [MESH] |Heme Oxygenase-1/metabolism [MESH] |Humans [MESH] |Interleukin-1beta/*pharmacology [MESH] |Lignans/*pharmacology [MESH] |Matrix Metalloproteinases, Secreted/metabolism [MESH] |Middle Aged [MESH] |NF-E2-Related Factor 2/genetics/*metabolism [MESH] |NF-KappaB Inhibitor alpha/metabolism [MESH] |Nitric Oxide/metabolism [MESH] |Osteoarthritis, Knee/*drug therapy/genetics/immunology/metabolism [MESH] |Phosphorylation [MESH] |RNA Interference [MESH] |Signal Transduction/*drug effects [MESH] |Transcription Factor RelA/metabolism [MESH]Sesamin inhibits IL-1?-stimulated inflammatory response in human osteo(epmc).pdf DeepDyve Pubget Overpricing