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10.18632/oncotarget.13299 http://scihub22266oqcxt.onion/10.18632/oncotarget.13299 C5347797!5347797 !27845909     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27845909 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (50 ): 83684-83700 Nephropedia Template TP {{tp|p=27845909 |t=2016. Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition |pdf=|usr=}}{{27845909 }} gab.com Text Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27845909 #FOAvip Recently platelet derived growth factor receptor-alpha (PDGFR?) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association with lymph node metastases. However, it is unclear how PDGFR? potentiates metastases and if it works through the canonical MAPK pathway traditionally linked to PTC oncogenesis. We explored the phenotypic changes driven by PDGFR? activation in human papillary thyroid cancer (PTC) cells and the downstream signalling cascades through which they are effected. We demonstrate that PDGFR? drives an impressive phenotypic change in PTC cell lines as documented by significant cytoskeletal rearrangement, increased migratory potential, and the formation of invadopodia. Cells lacking PDGFR? formed compact and dense spheroids, whereas cells expressing active PDGFR? exhibited invadopodia in three-dimensional culture. To achieve this, active PDGFR? provoked downstream activation of the MAPK/Erk, PI3K/Akt and STAT3 pathways. We further confirmed the role of PDGFR? as a transformative agent promoting the epithelial to mesenchymal transition of PTC cells, through the augmentation of Snail and Slug expression. Crenolanib, a small molecule inhibitor of PDGFR?, suppressed the levels of Snail and Slug and almost completely reversed all the phenotypic changes. We demonstrate that PDGFR? activation is an essential component that drives aggressiveness in PTC cells, and that the signaling pathways are complex, involving not only the MAPK/Erk but also the PI3K/Akt and STAT3 pathways. This argues for upstream targeting of the PDGFR? given the redundancy of oncogenic pathways in PTC, especially in patients whose tumors over-express this tyrosine kinase receptor. Twit Text FOAVip Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27845909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27845909 #FOAvip English Wikipedia <ref>{{Cite pmid|27845909 }}</ref> Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition #MMPMID27845909 Ekpe-Adewuyi E ; Lopez-Campistrous A ; Tang X ; Brindley DN ; McMullen TP Oncotarget 2016[Dec]; 7 (50 ): 83684-83700 PMID27845909 show ga Recently platelet derived growth factor receptor-alpha (PDGFR?) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association with lymph node metastases. However, it is unclear how PDGFR? potentiates metastases and if it works through the canonical MAPK pathway traditionally linked to PTC oncogenesis. We explored the phenotypic changes driven by PDGFR? activation in human papillary thyroid cancer (PTC) cells and the downstream signalling cascades through which they are effected. We demonstrate that PDGFR? drives an impressive phenotypic change in PTC cell lines as documented by significant cytoskeletal rearrangement, increased migratory potential, and the formation of invadopodia. Cells lacking PDGFR? formed compact and dense spheroids, whereas cells expressing active PDGFR? exhibited invadopodia in three-dimensional culture. To achieve this, active PDGFR? provoked downstream activation of the MAPK/Erk, PI3K/Akt and STAT3 pathways. We further confirmed the role of PDGFR? as a transformative agent promoting the epithelial to mesenchymal transition of PTC cells, through the augmentation of Snail and Slug expression. Crenolanib, a small molecule inhibitor of PDGFR?, suppressed the levels of Snail and Slug and almost completely reversed all the phenotypic changes. We demonstrate that PDGFR? activation is an essential component that drives aggressiveness in PTC cells, and that the signaling pathways are complex, involving not only the MAPK/Erk but also the PI3K/Akt and STAT3 pathways. This argues for upstream targeting of the PDGFR? given the redundancy of oncogenic pathways in PTC, especially in patients whose tumors over-express this tyrosine kinase receptor. |*Epithelial-Mesenchymal Transition/drug effects [MESH] |Antineoplastic Agents/pharmacology [MESH] |Benzimidazoles/pharmacology [MESH] |Carcinoma, Papillary/drug therapy/genetics/*metabolism/secondary [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cytoskeleton/metabolism/pathology [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Humans [MESH] |Lymphatic Metastasis [MESH] |Phenotype [MESH] |Phosphatidylinositol 3-Kinase/metabolism [MESH] |Piperidines/pharmacology [MESH] |Podosomes/metabolism/pathology [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Receptor, Platelet-Derived Growth Factor alpha/antagonists & inhibitors/genetics/*metabolism [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction [MESH] |Snail Family Transcription Factors/metabolism [MESH] |Thyroid Cancer, Papillary [MESH] |Thyroid Neoplasms/drug therapy/genetics/*metabolism/pathology [MESH]Platelet derived growth factor receptor alpha mediates nodal metastase(epmc).pdf DeepDyve Pubget Overpricing