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10.18632/oncotarget.13271 http://scihub22266oqcxt.onion/10.18632/oncotarget.13271 C5347793!5347793 !27845898     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27845898 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression |pdf=|usr=}}{{27845898 }} gab.com Text Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27845898 #FOAvip The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF to DNMT1 stimulated DNMT1 activity and FQI1 negated the methyltransferase activation. Addition of FQI1 to the cell culture disrupted LSF bound DNMT1 and UHRF1 complexes, resulting in global aberrant CpG methylation. Differentially methylated regions (DMR) containing at least 3 CpGs, were significantly altered by FQI1 compared to control cells. The DMRs were mostly concentrated in CpG islands, proximal to transcription start sites, and in introns and known genes. These DMRs represented both hypo and hypermethylation, correlating with altered gene expression. FQI1 treatment elicits a cascade of effects promoting altered cell cycle progression. These findings demonstrate a novel mechanism of FQI1 mediated alteration of the epigenome by DNMT1-LSF complex disruption, leading to aberrant DNA methylation and gene expression. Twit Text FOAVip Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27845898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27845898 #FOAvip English Wikipedia <ref>{{Cite pmid|27845898 }}</ref> Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression #MMPMID27845898 Chin HG ; Ponnaluri VK ; Zhang G ; Estève PO ; Schaus SE ; Hansen U ; Pradhan S Oncotarget 2016[Dec]; 7 (50 ): 83627-83640 PMID27845898 show ga The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF to DNMT1 stimulated DNMT1 activity and FQI1 negated the methyltransferase activation. Addition of FQI1 to the cell culture disrupted LSF bound DNMT1 and UHRF1 complexes, resulting in global aberrant CpG methylation. Differentially methylated regions (DMR) containing at least 3 CpGs, were significantly altered by FQI1 compared to control cells. The DMRs were mostly concentrated in CpG islands, proximal to transcription start sites, and in introns and known genes. These DMRs represented both hypo and hypermethylation, correlating with altered gene expression. FQI1 treatment elicits a cascade of effects promoting altered cell cycle progression. These findings demonstrate a novel mechanism of FQI1 mediated alteration of the epigenome by DNMT1-LSF complex disruption, leading to aberrant DNA methylation and gene expression. |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Benzodioxoles/*pharmacology [MESH] |CCAAT-Enhancer-Binding Proteins/genetics/metabolism [MESH] |COS Cells [MESH] |Carcinoma, Hepatocellular/*drug therapy/enzymology/genetics/pathology [MESH] |Cell Cycle/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Chlorocebus aethiops [MESH] |CpG Islands [MESH] |DNA (Cytosine-5-)-Methyltransferase 1/*genetics/metabolism [MESH] |DNA Methylation/*drug effects [MESH] |DNA-Binding Proteins/*genetics/metabolism [MESH] |Epigenesis, Genetic/*drug effects [MESH] |Gene Expression Regulation, Neoplastic/*drug effects [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Liver Neoplasms/*drug therapy/enzymology/genetics/pathology [MESH] |Protein Binding [MESH] |Quinolones/*pharmacology [MESH] |Transcription Factors/*genetics/metabolism [MESH] |Transfection [MESH]Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to a(epmc).pdf DeepDyve Pubget Overpricing