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10.18632/oncotarget.13076 http://scihub22266oqcxt.onion/10.18632/oncotarget.13076 C5347760!5347760 !27825121     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27825121 &cmd=llinks): Failed to open stream: HTTP request failed! 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Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis |pdf=|usr=}}{{27825121 }} gab.com Text Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27825121 #FOAvip BACKGROUND: Many studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development. An increased level of H19 was also associated with poor clinical outcomes of cancer patients. RESULTS: 12 eligible studies were screened, with a total of 1437 cancer patients. From the results of meta-analysis, as for prognosis, the patients with high expression of lncRNA H19 were shorter in OS (HR=1.08, 95% CI: 1.05-1.12). Statistical significance was also showed in subgroup meta-analysis stratified by the cancer type, analysis type and sample size. In addition, the patients detected with high H19 expression may be poorer in DFS (HR=1.27; 95% CI = 0.97-1.56). As for clinicopathology, it showed that increased H19 was related to poor histological grades (OR=2.31, 95% CI: 1.12-4.75), positive lymph node metastasis (OR=2.29, 95 % CI: 1.21-4.34) and advanced clinical stage (OR=4.83, 95% CI: 3.16-7.39). MATERIALS AND METHODS: Eligible studies were collected by retrieving keywords in PubMed, Web of Science, Embase, CNKI and Wanfang database, from 1966 to April 23, 2016. This quantitative meta-analysis was performed with Stata SE12.0 and RevMan5.3 software. It aimed to explore the association between H19 expression level and prognosis and clinicopathology. CONCLUSIONS: LncRNA-H19 may be a novel molecular marker for predicting solid tumors. It can also be a predictive factor of clinicopathological features in various cancers. Further studies are needed to verify the clinical utility of H19 in human cancers. Twit Text FOAVip Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27825121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27825121 #FOAvip English Wikipedia <ref>{{Cite pmid|27825121 }}</ref> Prognostic and clinicopathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis #MMPMID27825121 Liu FT ; Pan H ; Xia GF ; Qiu C ; Zhu ZM Oncotarget 2016[Dec]; 7 (50 ): 83177-83186 PMID27825121 show ga BACKGROUND: Many studies have reported that the expression level of lncRNA H19 was increased in various tumors. LncRNA H19 may play a significant role in cancer occurrence and development. An increased level of H19 was also associated with poor clinical outcomes of cancer patients. RESULTS: 12 eligible studies were screened, with a total of 1437 cancer patients. From the results of meta-analysis, as for prognosis, the patients with high expression of lncRNA H19 were shorter in OS (HR=1.08, 95% CI: 1.05-1.12). Statistical significance was also showed in subgroup meta-analysis stratified by the cancer type, analysis type and sample size. In addition, the patients detected with high H19 expression may be poorer in DFS (HR=1.27; 95% CI = 0.97-1.56). As for clinicopathology, it showed that increased H19 was related to poor histological grades (OR=2.31, 95% CI: 1.12-4.75), positive lymph node metastasis (OR=2.29, 95 % CI: 1.21-4.34) and advanced clinical stage (OR=4.83, 95% CI: 3.16-7.39). MATERIALS AND METHODS: Eligible studies were collected by retrieving keywords in PubMed, Web of Science, Embase, CNKI and Wanfang database, from 1966 to April 23, 2016. This quantitative meta-analysis was performed with Stata SE12.0 and RevMan5.3 software. It aimed to explore the association between H19 expression level and prognosis and clinicopathology. CONCLUSIONS: LncRNA-H19 may be a novel molecular marker for predicting solid tumors. It can also be a predictive factor of clinicopathological features in various cancers. Further studies are needed to verify the clinical utility of H19 in human cancers. |Biomarkers, Tumor/*genetics [MESH] |Chi-Square Distribution [MESH] |Disease-Free Survival [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Genetic Association Studies [MESH] |Genetic Predisposition to Disease [MESH] |Humans [MESH] |Lymphatic Metastasis [MESH] |Multivariate Analysis [MESH] |Neoplasm Grading [MESH] |Neoplasm Staging [MESH] |Neoplasms/*genetics/mortality/pathology/therapy [MESH] |Odds Ratio [MESH] |Phenotype [MESH] |RNA, Long Noncoding/*genetics [MESH] |Risk Factors [MESH] |Time Factors [MESH] |Tumor Burden [MESH]Prognostic and clinicopathological significance of long noncoding RNA (epmc).pdf DeepDyve Pubget Overpricing