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10.18632/oncotarget.12655 http://scihub22266oqcxt.onion/10.18632/oncotarget.12655 C5347738!5347738 !27756878     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27756878 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27756878 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (50 ): 82864-82875 Nephropedia Template TP {{tp|p=27756878 |t=2016. Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production |pdf=|usr=}}{{27756878 }} gab.com Text Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27756878 #FOAvip Plumbagin is a quinonoid constituent extracted from Plumbago genus, and it exhibits diverse pharmacological effects. This study thoroughly investigated the effects of plumbagin on thioacetamide-induced acute and chronic liver injury. Results shown that plumbagin increased survival rate, reduced liver congestion and inflammation, and decreased macrophages and neutrophils in the fulminant hepatic failure model, and remarkably diminished liver fibrosis and inflammation in the chronic liver injury model. Furthermore, plumbagin significantly suppress the HSCs/myofibroblasts activation by reduced expression of markers ?-SMA and COL-1/3, and reduced macrophage in liver. In the in vitro study, plumbagin induced apoptosis and suppressed the proliferation of LX-2 cells (human HSCs). Plumbagin treatment increased AMPK phosphorylation and attenuated NF-?B, STAT3, and Akt/mTOR signals in LX-2 cells, while SMAD2 phosphorylation was not changed. Noticeably, plumbagin promoted AMPK binding to p300 which is a cofactor of SMAD complex, this may further competitively decreases the p300/SMAD complex initiated transcription of COL-1/3 and ?-SMA. Additionally, plumbagin hampered inflammation related NF-?B signal in RAW 264.7 cells. In conclusion, these findings indicate that plumbagin may be a powerful drug candidate to protect the liver from acute and chronic damage by inhibiting inflammation and collagen production. Twit Text FOAVip Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27756878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27756878 #FOAvip English Wikipedia <ref>{{Cite pmid|27756878 }}</ref> Plumbagin protects liver against fulminant hepatic failure and chronic liver fibrosis via inhibiting inflammation and collagen production #MMPMID27756878 Wang H ; Zhang H ; Zhang Y ; Wang D ; Cheng X ; Yang F ; Zhang Q ; Xue Z ; Li Y ; Zhang L ; Yang L ; Miao G ; Li D ; Guan Z ; Da Y ; Yao Z ; Gao F ; Qiao L ; Kong L ; Zhang R Oncotarget 2016[Dec]; 7 (50 ): 82864-82875 PMID27756878 show ga Plumbagin is a quinonoid constituent extracted from Plumbago genus, and it exhibits diverse pharmacological effects. This study thoroughly investigated the effects of plumbagin on thioacetamide-induced acute and chronic liver injury. Results shown that plumbagin increased survival rate, reduced liver congestion and inflammation, and decreased macrophages and neutrophils in the fulminant hepatic failure model, and remarkably diminished liver fibrosis and inflammation in the chronic liver injury model. Furthermore, plumbagin significantly suppress the HSCs/myofibroblasts activation by reduced expression of markers ?-SMA and COL-1/3, and reduced macrophage in liver. In the in vitro study, plumbagin induced apoptosis and suppressed the proliferation of LX-2 cells (human HSCs). Plumbagin treatment increased AMPK phosphorylation and attenuated NF-?B, STAT3, and Akt/mTOR signals in LX-2 cells, while SMAD2 phosphorylation was not changed. Noticeably, plumbagin promoted AMPK binding to p300 which is a cofactor of SMAD complex, this may further competitively decreases the p300/SMAD complex initiated transcription of COL-1/3 and ?-SMA. Additionally, plumbagin hampered inflammation related NF-?B signal in RAW 264.7 cells. In conclusion, these findings indicate that plumbagin may be a powerful drug candidate to protect the liver from acute and chronic damage by inhibiting inflammation and collagen production. |AMP-Activated Protein Kinases/metabolism [MESH] |Animals [MESH] |Anti-Inflammatory Agents/*pharmacology [MESH] |Apoptosis/drug effects [MESH] |Chemical and Drug Induced Liver Injury/metabolism/pathology/*prevention & control [MESH] |Collagen Type I/*metabolism [MESH] |Collagen Type III/*metabolism [MESH] |Cytoprotection [MESH] |Female [MESH] |Hepatic Stellate Cells/drug effects/metabolism/pathology [MESH] |Humans [MESH] |Liver Cirrhosis, Experimental/chemically induced/metabolism/pathology/*prevention & control [MESH] |Liver Failure, Acute/chemically induced/metabolism/pathology/*prevention & control [MESH] |Liver Regeneration/drug effects [MESH] |Liver/*drug effects/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred ICR [MESH] |Myofibroblasts/drug effects/metabolism/pathology [MESH] |NF-kappa B/metabolism [MESH] |Naphthoquinones/*pharmacology [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RAW 264.7 Cells [MESH] |STAT3 Transcription Factor/metabolism [MESH] |Signal Transduction/drug effects [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Thioacetamide [MESH]Plumbagin protects liver against fulminant hepatic failure and chronic(epmc).pdf DeepDyve Pubget Overpricing