Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28274108
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gut+Liver
2017 ; 11
(2
): 196-208
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge
between Functional Organic Dichotomy
#MMPMID28274108
Ghoshal UC
; Shukla R
; Ghoshal U
Gut Liver
2017[Mar]; 11
(2
): 196-208
PMID28274108
show ga
The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely
psychogenic in origin, is now understood to be multifactorial. One of the reasons
for this paradigm shift is the realization that gut dysbiosis, including small
intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78%
of patients with IBS and 1% and 40% of controls have SIBO; such wide variations
in prevalence might result from population differences, IBS diagnostic criteria,
and, most importantly, methods to diagnose SIBO. Although quantitative jejunal
aspirate culture is considered the gold standard for the diagnosis of SIBO,
noninvasive hydrogen breath tests have been popular. Although the glucose
hydrogen breath test is highly specific, its sensitivity is low; in contrast, the
early-peak criteria in the lactulose hydrogen breath test are highly nonspecific.
Female gender, older age, diarrhea-predominant IBS, bloating and flatulence,
proton pump inhibitor and narcotic intake, and low hemoglobin are associated with
SIBO among IBS patients. Several therapeutic trials targeting gut microbes using
antibiotics and probiotics have further demonstrated that not all symptoms in
patients with IBS originate in the brain but rather in the gut, providing support
for the micro-organic basis of IBS. A recent proof-of-concept study showing the
high frequency of symptom improvement in patients with IBS with SIBO further
supports this hypothesis.