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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (10): 2622-7 Nephropedia Template TP
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Geometry and network connectivity govern the mechanics of stress fibers #MMPMID28213499
Kassianidou E; Brand CA; Schwarz US; Kumar S
Proc Natl Acad Sci U S A 2017[Mar]; 114 (10): 2622-7 PMID28213499show ga
Actomyosin stress fiber (SF) networks transmit tension to the microenvironment, which contributes to cell shape and tissue assembly. However, virtually nothing is known about how SF geometry and network structure control the ability of an SF to generate tension. We normalized cell shape and SF length with micropatterning and used laser ablation to probe the viscoelastic properties of the resulting standardized SFs. We find that the retraction dynamics of a cut SF are strongly regulated by SF length, and this relationship may be amplified or offset by the orientation of the attached SFs in single cells as well as in a monolayer. Thus, SF force generation is controlled both locally via adhesive geometry and globally via connections to the actin network.