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10.1073/pnas.1613300114 http://scihub22266oqcxt.onion/10.1073/pnas.1613300114 C5347632!5347632!28223506     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (10): E1885-94 Nephropedia Template TP {{tp|p=28223506|t=2017. Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes |pdf=|usr=}}{{28223506}} gab.com Text Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28223506 #FOAvip The decision-making process of cellular phenotype specification is controlled by the interplay between genetic and epigenetic elements. Intragenic CGIs (iCGIs) associated with developmental regulators have sequence features that favor DNA methylation and bivalent histone modification, i.e., both activating histone H3 lysine 4 trimethylation and repressing H3K27me3 marks. The epigenetic transition from bivalent modification to DNA methylation on iCGIs during differentiation results in cell type-specific activation of their associated genes. This process is accompanied by loss of physical interactions with promoter regions, and the motifs of developmental regulators are enriched at iCGIs, indicating involvement of these regulators in the epigenetic transition. Our work uncovers the role of iCGIs in cell type-specific differentiation. Twit Text FOAVip Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28223506 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28223506 #FOAvip English Wikipedia <ref>{{Cite pmid|28223506}}</ref> Intragenic CpG islands play important roles in bivalent chromatin assembly of developmental genes #MMPMID28223506 Lee SM; Lee J; Noh KM; Choi WY; Jeon S; Oh GT; Kim-Ha J; Jin Y; Cho SW; Kim YJ Proc Natl Acad Sci U S A 2017[Mar]; 114 (10): E1885-94 PMID28223506show ga The decision-making process of cellular phenotype specification is controlled by the interplay between genetic and epigenetic elements. Intragenic CGIs (iCGIs) associated with developmental regulators have sequence features that favor DNA methylation and bivalent histone modification, i.e., both activating histone H3 lysine 4 trimethylation and repressing H3K27me3 marks. The epigenetic transition from bivalent modification to DNA methylation on iCGIs during differentiation results in cell type-specific activation of their associated genes. This process is accompanied by loss of physical interactions with promoter regions, and the motifs of developmental regulators are enriched at iCGIs, indicating involvement of these regulators in the epigenetic transition. Our work uncovers the role of iCGIs in cell type-specific differentiation. äIntragenic CpG islands play important roles in bivalent chromatin asse(epmc).pdf DeepDyve Pubget Overpricing