Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1701529114 http://scihub22266oqcxt.onion/10.1073/pnas.1701529114 C5347553!5347553!28223524     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28223524.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (10): 2562-7 Nephropedia Template TP {{tp|p=28223524|t=2017. Distinct conformations of GPCR??-arrestin complexes mediate desensitization, signaling, and endocytosis |pdf=|usr=}}{{28223524}} gab.com Text Distinct conformations of GPCR -arrestin complexes mediate desensitization, signaling, and endocytosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28223524 #FOAvip ?-Arrestins (?arrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis. Using a panel of GPCRs believed to couple differently to ?arrs, we demonstrate how distinct conformations of GPCR??arr complexes are specialized to perform different subsets of these cellular functions. Our results thus provide a new signaling paradigm for the understanding of GPCRs, whereby a specific GPCR??arr conformation mediates receptor desensitization, and another drives internalization and some forms of signaling. Twit Text FOAVip Distinct conformations of GPCR -arrestin complexes mediate desensitization, signaling, and endocytosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28223524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28223524 #FOAvip English Wikipedia <ref>{{Cite pmid|28223524}}</ref> Distinct conformations of GPCR??-arrestin complexes mediate desensitization, signaling, and endocytosis #MMPMID28223524 Cahill TJ; Thomsen ARB; Tarrasch JT; Plouffe B; Nguyen AH; Yang F; Huang LY; Kahsai AW; Bassoni DL; Gavino BJ; Lamerdin JE; Triest S; Shukla AK; Berger B; Little J; Antar A; Blanc A; Qu CX; Chen X; Kawakami K; Inoue A; Aoki J; Steyaert J; Sun JP; Bouvier M; Skiniotis G; Lefkowitz RJ Proc Natl Acad Sci U S A 2017[Mar]; 114 (10): 2562-7 PMID28223524show ga ?-Arrestins (?arrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis. Using a panel of GPCRs believed to couple differently to ?arrs, we demonstrate how distinct conformations of GPCR??arr complexes are specialized to perform different subsets of these cellular functions. Our results thus provide a new signaling paradigm for the understanding of GPCRs, whereby a specific GPCR??arr conformation mediates receptor desensitization, and another drives internalization and some forms of signaling. äDistinct conformations of GPCR??-arrestin complexes mediate desensitiz(epmc).pdf DeepDyve Pubget Overpricing