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2017 ; 15
(1
): 1559325817692903
Nephropedia Template TP
gab.com Text
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English Wikipedia
Evidence That Lifelong Low Dose Rates of Ionizing Radiation Increase Lifespan in
Long- and Short-Lived Dogs
#MMPMID28321175
Cuttler JM
; Feinendegen LE
; Socol Y
Dose Response
2017[Jan]; 15
(1
): 1559325817692903
PMID28321175
show ga
After the 1956 radiation scare to stop weapons testing, studies focused on cancer
induction by low-level radiation. Concern has shifted to protecting
"radiation-sensitive individuals." Since longevity is a measure of health impact,
this analysis reexamined data to compare the effect of dose rate on the lifespans
of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50%
mortality. The data came from 2 large-scale studies. One exposed 10 groups to
different ? dose rates; the other exposed 8 groups to different lung burdens of
plutonium. Reexamination indicated that normalized lifespans increased more for
short-lived dogs than for average dogs, when radiation was moderately above
background. This was apparent by interpolating between the lifespans of
nonirradiated dogs and exposed dogs. The optimum lifespan increase appeared at 50
mGy/y. The threshold for harm (decreased lifespan) was 700 mGy/y for 50%
mortality dogs and 1100 mGy/y for short-lived dogs. For inhaled ?-emitting
particulates, longevity was remarkably increased for short-lived dogs below the
threshold for harm. Short-lived dogs seem more radiosensitive than average dogs
and they benefit more from low radiation. If dogs model humans, this evidence
would support a change to radiation protection policy. Maintaining exposures "as
low as reasonably achievable" (ALARA) appears questionable.