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10.1038/srep44357 http://scihub22266oqcxt.onion/10.1038/srep44357 C5347013!5347013!28287155     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28287155|t=2017. Bystander cells enhance NK cytotoxic efficiency by reducing search time |pdf=|usr=}}{{28287155}} gab.com Text Bystander cells enhance NK cytotoxic efficiency by reducing search time JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28287155 #FOAvip Natural killer (NK) cells play a central role during innate immune responses by eliminating pathogen-infected or tumorigenic cells. In the microenvironment, NK cells encounter not only target cells but also other cell types including non-target bystander cells. The impact of bystander cells on NK killing efficiency is, however, still elusive. In this study we show that the presence of bystander cells, such as P815, monocytes or HUVEC, enhances NK killing efficiency. With bystander cells present, the velocity and persistence of NK cells were increased, whereas the degranulation of lytic granules remained unchanged. Bystander cell-derived H2O2 was found to mediate the acceleration of NK cell migration. Using mathematical diffusion models, we confirm that local acceleration of NK cells in the vicinity of bystander cells reduces their search time to locate target cells. In addition, we found that integrin ? chains (?1, ?2 and ?7) on NK cells are required for bystander-enhanced NK migration persistence. In conclusion, we show that acceleration of NK cell migration in the vicinity of H2O2-producing bystander cells reduces target cell search time and enhances NK killing efficiency. Twit Text FOAVip Bystander cells enhance NK cytotoxic efficiency by reducing search time ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28287155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28287155 #FOAvip English Wikipedia <ref>{{Cite pmid|28287155}}</ref> Bystander cells enhance NK cytotoxic efficiency by reducing search time #MMPMID28287155 Zhou X; Zhao R; Schwarz K; Mangeat M; Schwarz EC; Hamed M; Bogeski I; Helms V; Rieger H; Qu B Sci Rep 2017[]; 7 (ä): ä PMID28287155show ga Natural killer (NK) cells play a central role during innate immune responses by eliminating pathogen-infected or tumorigenic cells. In the microenvironment, NK cells encounter not only target cells but also other cell types including non-target bystander cells. The impact of bystander cells on NK killing efficiency is, however, still elusive. In this study we show that the presence of bystander cells, such as P815, monocytes or HUVEC, enhances NK killing efficiency. With bystander cells present, the velocity and persistence of NK cells were increased, whereas the degranulation of lytic granules remained unchanged. Bystander cell-derived H2O2 was found to mediate the acceleration of NK cell migration. Using mathematical diffusion models, we confirm that local acceleration of NK cells in the vicinity of bystander cells reduces their search time to locate target cells. In addition, we found that integrin ? chains (?1, ?2 and ?7) on NK cells are required for bystander-enhanced NK migration persistence. In conclusion, we show that acceleration of NK cell migration in the vicinity of H2O2-producing bystander cells reduces target cell search time and enhances NK killing efficiency. äBystander cells enhance NK cytotoxic efficiency by reducing search tim(epmc).pdf DeepDyve Pubget Overpricing