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10.18632/oncotarget.12972

http://scihub22266oqcxt.onion/10.18632/oncotarget.12972
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C5346752!5346752 !27806334
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suck abstract from ncbi


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pmid27806334
      Oncotarget 2016 ; 7 (48 ): 79805-79813
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  • MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3?/STAT3/HIF-1?/VEGF signaling #MMPMID27806334
  • Xue D ; Yang Y ; Liu Y ; Wang P ; Dai Y ; Liu Q ; Chen L ; Shen J ; Ju H ; Li Y ; Tan Z
  • Oncotarget 2016[Nov]; 7 (48 ): 79805-79813 PMID27806334 show ga
  • Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Angiogenesis is the major hallmark in NSCLC. So, further elucidation of molecular mechanisms underlying the angiogenesis of NSCLC is urgently needed. Here, we found that microRNA-206 (miR-206) decreased the angiogenic ability in NSCLC via inhibiting the 14-3-3?/STAT3/HIF-1?/VEGF pathway. Briefly, 14-3-3? bond with phosphorylated-STAT3, and in turn, elevated the expression of HIF-1?. Then, by enhancing the recruitment of HIF-1? to VEGF promoter, 14-3-3? increased the angiogenesis. However, miR-206 decreased the angiogenesis by targeting 14-3-3?, and inhibiting the STAT3/HIF-1?/VEGF pathway. In NSCLC cell xenograft model, either overexpression of miR-206 or inhibition of 14-3-3? inhibited the STAT3/HIF-1?/VEGF pathway and decreased the tumor growth and angiogenesis. Furthermore, there was a negative correlation between miR-206 and 14-3-3? in NSCLC specimens. NSCLC patients with low expressions of miR-206 but high expressions of 14-3-3? had the worst survival. Collectively, our findings provided the underlying mechanisms of miR-206/14-3-3? in tumor growth and angiogenesis, and implicated miR-206 and 14-3-3? as potential therapeutic targets for NSCLC.
  • |14-3-3 Proteins/metabolism [MESH]
  • |A549 Cells [MESH]
  • |Animals [MESH]
  • |Carcinoma, Non-Small-Cell Lung/blood supply/*genetics/*pathology [MESH]
  • |Cell Proliferation/*genetics [MESH]
  • |Cells, Cultured [MESH]
  • |Human Umbilical Vein Endothelial Cells [MESH]
  • |Humans [MESH]
  • |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH]
  • |Lung Neoplasms/blood supply/*genetics/*pathology [MESH]
  • |Mice [MESH]
  • |Mice, Inbred BALB C [MESH]
  • |Mice, Nude [MESH]
  • |MicroRNAs/genetics/*physiology [MESH]
  • |Neovascularization, Pathologic/*genetics [MESH]
  • |STAT3 Transcription Factor/metabolism [MESH]
  • |Signal Transduction/genetics [MESH]


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