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10.18632/oncotarget.12873 http://scihub22266oqcxt.onion/10.18632/oncotarget.12873 C5346740!5346740!27793031     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (48): 79617-28 Nephropedia Template TP {{tp|p=27793031|t=2016. miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts |pdf=|usr=}}{{27793031}} gab.com Text miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27793031 #FOAvip Autophagy is a double-edged sword in tumor development. Recent studies have found that miRNAs have an inhibitory effect on the regulation of autophagy. It has been reported that miR-31 plays an important role in the development of colorectal cancer. However, what role miR-31 plays in colorectal cancer-associated fibroblasts (CAFs) has not been determined. In this study, we confirmed that the expression of miR-31 in CAFs was higher than in normal colorectal fibroblasts (NFs). We also found that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3. In addition, we found up-regulation of miR-31 significantly affected colorectal cancer cell behaviors, including proliferation, invasion and apoptosis. Also, up-regulation of miR-31 in CAF could increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. In summary, miR-31 can inhibit autophagy in colorectal CAFs, affect colorectal cancer development, and increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. We hypothesize that miR-31 may become a new target of treatments for colorectal cancer. Twit Text FOAVip miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27793031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27793031 #FOAvip English Wikipedia <ref>{{Cite pmid|27793031}}</ref> miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts #MMPMID27793031 Yang X; Xu X; Zhu J; Zhang S; Wu Y; Wu Y; Zhao K; Xing C; Cao J; Zhu H; Li M; Ye Z; Peng W Oncotarget 2016[Nov]; 7 (48): 79617-28 PMID27793031show ga Autophagy is a double-edged sword in tumor development. Recent studies have found that miRNAs have an inhibitory effect on the regulation of autophagy. It has been reported that miR-31 plays an important role in the development of colorectal cancer. However, what role miR-31 plays in colorectal cancer-associated fibroblasts (CAFs) has not been determined. In this study, we confirmed that the expression of miR-31 in CAFs was higher than in normal colorectal fibroblasts (NFs). We also found that treatment of CAFs with miR-31 mimic inhibited the expression of the autophagy-related genes Beclin-1, ATG, DRAM and LC3. In addition, we found up-regulation of miR-31 significantly affected colorectal cancer cell behaviors, including proliferation, invasion and apoptosis. Also, up-regulation of miR-31 in CAF could increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. In summary, miR-31 can inhibit autophagy in colorectal CAFs, affect colorectal cancer development, and increase the radiosensitivity of colorectal cancer cells co-cultured with CAF. We hypothesize that miR-31 may become a new target of treatments for colorectal cancer. ämiR-31 affects colorectal cancer cells by inhibiting autophagy in canc(epmc).pdf DeepDyve Pubget Overpricing