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10.18632/oncotarget.11823 http://scihub22266oqcxt.onion/10.18632/oncotarget.11823 C5346667!5346667 !27602953     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27602953 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy |pdf=|usr=}}{{27602953 }} gab.com Text Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602953 #FOAvip Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways involved in apoptotic cell recognition and phagocytosis, irradiated cancer cells engender suppressive phenotypes in macrophages. We demonstrate that the macrophage-specific phagocytic receptor, Mertk is upregulated in macrophages in the tumor following radiation therapy. Ligation of Mertk on macrophages results in anti-inflammatory cytokine responses via NF-kB p50 upregulation, which in turn limits tumor control following radiation therapy. We demonstrate that in immunogenic tumors, loss of Mertk is sufficient to permit tumor cure following radiation therapy. However, in poorly immunogenic tumors, TGF? inhibition is also required to result in tumor cure following radiation therapy. These data demonstrate that Mertk is a highly specific target whose absence permits tumor control in combination with radiation therapy. Twit Text FOAVip Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27602953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602953 #FOAvip English Wikipedia <ref>{{Cite pmid|27602953 }}</ref> Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy #MMPMID27602953 Crittenden MR ; Baird J ; Friedman D ; Savage T ; Uhde L ; Alice A ; Cottam B ; Young K ; Newell P ; Nguyen C ; Bambina S ; Kramer G ; Akporiaye E ; Malecka A ; Jackson A ; Gough MJ Oncotarget 2016[Nov]; 7 (48 ): 78653-78666 PMID27602953 show ga Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways involved in apoptotic cell recognition and phagocytosis, irradiated cancer cells engender suppressive phenotypes in macrophages. We demonstrate that the macrophage-specific phagocytic receptor, Mertk is upregulated in macrophages in the tumor following radiation therapy. Ligation of Mertk on macrophages results in anti-inflammatory cytokine responses via NF-kB p50 upregulation, which in turn limits tumor control following radiation therapy. We demonstrate that in immunogenic tumors, loss of Mertk is sufficient to permit tumor cure following radiation therapy. However, in poorly immunogenic tumors, TGF? inhibition is also required to result in tumor cure following radiation therapy. These data demonstrate that Mertk is a highly specific target whose absence permits tumor control in combination with radiation therapy. |*Neoplasm Recurrence, Local [MESH] |Animals [MESH] |Antineoplastic Combined Chemotherapy Protocols/pharmacology [MESH] |Azabicyclo Compounds/pharmacology [MESH] |Cell Line, Tumor [MESH] |Coculture Techniques [MESH] |Cytokines/metabolism [MESH] |Macrophages/enzymology/immunology/pathology/*radiation effects [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |NF-kappa B/metabolism [MESH] |Neoplasms, Experimental/enzymology/immunology/pathology/*radiotherapy [MESH] |RAW 264.7 Cells [MESH] |Receptors, Transforming Growth Factor beta/antagonists & inhibitors/metabolism [MESH] |Recombinant Fusion Proteins/pharmacology [MESH] |Signal Transduction/radiation effects [MESH] |Time Factors [MESH] |Transforming Growth Factor beta/metabolism [MESH]Mertk on tumor macrophages is a therapeutic target to prevent tumor re(epmc).pdf DeepDyve Pubget Overpricing