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10.18632/oncotarget.12693 http://scihub22266oqcxt.onion/10.18632/oncotarget.12693 C5346666!5346666!27769047     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27769047&cmd=llinks): Failed to open stream: HTTP request failed! 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The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer |pdf=|usr=}}{{27769047}} gab.com Text The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27769047 #FOAvip Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo. Among all the changed miRNAs in miRNA profiling, miR-33a expression was significantly decreased in IL-6 treated GBC cell lines, as well as in GBC tissues compared with case-matched normal tissues and cholecystitis tissues. In turn, miR-33a suppresses IL-6?induced tumor metastasis by directly binding Twist which was identified as an EMT marker. High expression of miR-33a suppressed xenograft tumor growth and dissemination in nude mice. The downregulation of miR-33a was closely associated with advanced clinical stage, lymph node metastasis, and poor clinical outcomes in patients with GBC. miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC. Twit Text FOAVip The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27769047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27769047 #FOAvip English Wikipedia <ref>{{Cite pmid|27769047}}</ref> The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer #MMPMID27769047 Zhang M; Gong W; Zuo B; Chu B; Tang Z; Zhang Y; Yang Y; Zhou D; Weng M; Qin Y; Ma M; Jiang A; Ma F; Quan Z Oncotarget 2016[Nov]; 7 (48): 78640-52 PMID27769047show ga Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo. Among all the changed miRNAs in miRNA profiling, miR-33a expression was significantly decreased in IL-6 treated GBC cell lines, as well as in GBC tissues compared with case-matched normal tissues and cholecystitis tissues. In turn, miR-33a suppresses IL-6?induced tumor metastasis by directly binding Twist which was identified as an EMT marker. High expression of miR-33a suppressed xenograft tumor growth and dissemination in nude mice. The downregulation of miR-33a was closely associated with advanced clinical stage, lymph node metastasis, and poor clinical outcomes in patients with GBC. miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC. äThe microRNA miR-33a suppresses IL-6-induced tumor progression by bind(epmc).pdf DeepDyve Pubget Overpricing