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10.1002/brb3.646 http://scihub22266oqcxt.onion/10.1002/brb3.646 C5346528!5346528 !28293481     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28293481 &cmd=llinks): Failed to open stream: HTTP request failed! 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A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males |pdf=|usr=}}{{28293481 }} gab.com Text A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males JO: Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=28293481 #FOAvip INTRODUCTION: The enzyme steroid sulfatase (STS) converts sulfated steroids to their non-sulfated forms. Deficiency for this enzyme is associated with inattention but preserved response control. The polymorphism rs17268988 within the X-linked STS gene is associated with inattentive, but not other, symptoms in boys with attention deficit hyperactivity disorder (ADHD). METHODS: We initially tested whether rs17268988 genotype was associated with attention, response control, and underlying aspects of cognition, using questionnaires and neuropsychological tasks, in two independent cohorts of healthy adult males. In an additional analysis based upon existing data, the performance of mice with genetic or pharmacological manipulations of the STS axis under attentionally demanding conditions was investigated. RESULTS: G-allele carriers at rs17268988 exhibited reduced reaction time, enhanced attention, and reduced reaction time variability relative to C-allele carriers. Mice with genetic or pharmacological manipulations of the STS axis were shown to have perturbed reaction time variability. DISCUSSION: Our findings provide additional support for an association between rs17268988 genotype and attention, which may be partially mediated by reaction time variability; they also indicate that, in contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 is associated with enhanced cognition. As reaction time variability is a predictor of well-being, rs17268988 genotype may represent a biomarker for long-term health. Twit Text FOAVip A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males ????Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=28293481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28293481 #FOAvip English Wikipedia <ref>{{Cite pmid|28293481 }}</ref> A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males #MMPMID28293481 Humby T ; Fisher A ; Allen C ; Reynolds M ; Hartman A ; Giegling I ; Rujescu D ; Davies W Brain Behav 2017[Mar]; 7 (3 ): e00646 PMID28293481 show ga INTRODUCTION: The enzyme steroid sulfatase (STS) converts sulfated steroids to their non-sulfated forms. Deficiency for this enzyme is associated with inattention but preserved response control. The polymorphism rs17268988 within the X-linked STS gene is associated with inattentive, but not other, symptoms in boys with attention deficit hyperactivity disorder (ADHD). METHODS: We initially tested whether rs17268988 genotype was associated with attention, response control, and underlying aspects of cognition, using questionnaires and neuropsychological tasks, in two independent cohorts of healthy adult males. In an additional analysis based upon existing data, the performance of mice with genetic or pharmacological manipulations of the STS axis under attentionally demanding conditions was investigated. RESULTS: G-allele carriers at rs17268988 exhibited reduced reaction time, enhanced attention, and reduced reaction time variability relative to C-allele carriers. Mice with genetic or pharmacological manipulations of the STS axis were shown to have perturbed reaction time variability. DISCUSSION: Our findings provide additional support for an association between rs17268988 genotype and attention, which may be partially mediated by reaction time variability; they also indicate that, in contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 is associated with enhanced cognition. As reaction time variability is a predictor of well-being, rs17268988 genotype may represent a biomarker for long-term health. |Adult [MESH] |Animals [MESH] |Attention Deficit Disorder with Hyperactivity/genetics/*physiopathology [MESH] |Attention/*physiology [MESH] |Cognition/*physiology [MESH] |Cohort Studies [MESH] |Executive Function/*physiology [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Psychomotor Performance/*physiology [MESH] |Reaction Time/genetics/*physiology [MESH] |Steryl-Sulfatase/*genetics [MESH]A genetic variant within STS previously associated with inattention in(epmc).pdf DeepDyve Pubget Overpricing