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10.1002/brb3.624 http://scihub22266oqcxt.onion/10.1002/brb3.624 C5346513!5346513!28293466     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav 2017 ; 7 (3): ä Nephropedia Template TP {{tp|p=28293466|t=2017. CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material |pdf=|usr=}}{{28293466}} gab.com Text CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material JO: Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=28293466 #FOAvip Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary systemic vascular disorder. Granular osmiophilic material (GOM) is its ultrastructural marker. We reviewed tissue biopsies from CADASIL patients to establish whether ultrastructural observations help clarify the pathogenic mechanism of CADASIL. Given the resemblance of the GOM deposits to the immunoglobulin deposits seen in glomerulonephritis and focal segmental glomerulosclerosis (FSGS), their morphologies were investigated and compared. Methods: Skin, skeletal muscle, kidney, and pericardium tissue biopsies from 13 patients with a clinical and molecular diagnosis of CADASIL, and kidney biopsies from five patients with IgA nephropathy and five patients with primary FSGS were subjected to ultrastructural examination. Results: In CADASIL patients, several GOM deposits from all sites were partially or totally surrounded by an electron?lucent halo. The deposits frequently had a more electron?dense portion with a regular outline on the inner side and a less osmiophilic, looser outer side displaying a less regular profile. The uniformly dense deposits tended to be more osmiophilic if located close to the cell membrane and less osmiophilic if laid farther away from it. The immunoglobulin deposits from the glomerulonephritis and FSGS patients lacked both the granular pattern and the halo. Conclusions: This study demonstrates that GOM deposits may have a nonuniform morphology and describes in detail an electron?lucent halo surrounding several of them. It is conceivable that the halo is the morphological evidence and possibly the cause of an aberrant NOTCH3 processing, already suspected to be involved in CADASIL. Twit Text FOAVip CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material ????Brain Behav http://www.kidney.de/pget.php?&tw=1&pmid=28293466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28293466 #FOAvip English Wikipedia <ref>{{Cite pmid|28293466}}</ref> CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material #MMPMID28293466 Lorenzi T; Ragno M; Paolinelli F; Castellucci C; Scarpelli M; Morroni M Brain Behav 2017[Mar]; 7 (3): ä PMID28293466show ga Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary systemic vascular disorder. Granular osmiophilic material (GOM) is its ultrastructural marker. We reviewed tissue biopsies from CADASIL patients to establish whether ultrastructural observations help clarify the pathogenic mechanism of CADASIL. Given the resemblance of the GOM deposits to the immunoglobulin deposits seen in glomerulonephritis and focal segmental glomerulosclerosis (FSGS), their morphologies were investigated and compared. Methods: Skin, skeletal muscle, kidney, and pericardium tissue biopsies from 13 patients with a clinical and molecular diagnosis of CADASIL, and kidney biopsies from five patients with IgA nephropathy and five patients with primary FSGS were subjected to ultrastructural examination. Results: In CADASIL patients, several GOM deposits from all sites were partially or totally surrounded by an electron?lucent halo. The deposits frequently had a more electron?dense portion with a regular outline on the inner side and a less osmiophilic, looser outer side displaying a less regular profile. The uniformly dense deposits tended to be more osmiophilic if located close to the cell membrane and less osmiophilic if laid farther away from it. The immunoglobulin deposits from the glomerulonephritis and FSGS patients lacked both the granular pattern and the halo. Conclusions: This study demonstrates that GOM deposits may have a nonuniform morphology and describes in detail an electron?lucent halo surrounding several of them. It is conceivable that the halo is the morphological evidence and possibly the cause of an aberrant NOTCH3 processing, already suspected to be involved in CADASIL. äCADASIL: Ultrastructural insights into the morphology of granular osmi(epmc).pdf DeepDyve Pubget Overpricing