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10.1371/journal.pone.0173638 http://scihub22266oqcxt.onion/10.1371/journal.pone.0173638 C5345822!5345822 !28282434     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28282434 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2017 ; 12 (3 ): e0173638 Nephropedia Template TP {{tp|p=28282434 |t=2017. Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils |pdf=|usr=}}{{28282434 }} gab.com Text Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28282434 #FOAvip Hypervirulent Klebsiella pneumoniae (HvKP) is hypermucoviscous organism, carrying genes of rmpA and aerobactin, causing serious community-acquired infection and metastatically spread in young healthy hosts. Neutrophils play an important role during innate immune response against bacterial infection by phagocytosis and neutrophil extracellular traps (NETs). Whether neutrophils can effectively defend against HvKP remains unclear. In this study, we observed that the HvKP was significantly more resistant to neutrophil-mediated phagocytosis and intracellular killing than classic Klebsiella pneumoniae (cKP) isolates. Although both HvKP and cKP induced NETs under scanning electron microscopy and confocal microscopy, more cKP than HvKP were trapped in NETs, and the killing by intracellular and extracellular mechanisms of neutrophils was detected only on cKP. Together, our results demonstrated that HvKP resisted to both intracellular and extracellular killing of neutrophils. Twit Text FOAVip Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28282434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28282434 #FOAvip English Wikipedia <ref>{{Cite pmid|28282434 }}</ref> Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils #MMPMID28282434 Wang L ; Shen D ; Wu H ; Ma Y PLoS One 2017[]; 12 (3 ): e0173638 PMID28282434 show ga Hypervirulent Klebsiella pneumoniae (HvKP) is hypermucoviscous organism, carrying genes of rmpA and aerobactin, causing serious community-acquired infection and metastatically spread in young healthy hosts. Neutrophils play an important role during innate immune response against bacterial infection by phagocytosis and neutrophil extracellular traps (NETs). Whether neutrophils can effectively defend against HvKP remains unclear. In this study, we observed that the HvKP was significantly more resistant to neutrophil-mediated phagocytosis and intracellular killing than classic Klebsiella pneumoniae (cKP) isolates. Although both HvKP and cKP induced NETs under scanning electron microscopy and confocal microscopy, more cKP than HvKP were trapped in NETs, and the killing by intracellular and extracellular mechanisms of neutrophils was detected only on cKP. Together, our results demonstrated that HvKP resisted to both intracellular and extracellular killing of neutrophils. |*Klebsiella pneumoniae/immunology/pathogenicity [MESH] |*Phagocytosis [MESH] |Extracellular Traps/*immunology [MESH] |Female [MESH] |Humans [MESH] |Klebsiella Infections/*immunology/microbiology [MESH] |Male [MESH]Resistance of hypervirulent Klebsiella pneumoniae to both intracellula(epmc).pdf DeepDyve Pubget Overpricing