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10.1016/j.cmet.2017.02.007 http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.02.007 C5345693!5345693 !28273482     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28273482 &cmd=llinks): Failed to open stream: HTTP request failed! 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Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity |pdf=|usr=}}{{28273482 }} gab.com Text Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28273482 #FOAvip The gut microbiome participates in numerous physiologic functions and communicates intimately with the host immune system. Antimicrobial peptides are critical components of intestinal innate immunity. We report a prominent role for antimicrobials secreted by pancreatic acini in shaping the gut microbiome that is essential for intestinal innate immunity, barrier function, and survival. Deletion of the Ca(2+) channel Orai1 in pancreatic acini of adult mice resulted in 60%-70% mortality within 3 weeks. Despite robust activation of the intestinal innate immune response, mice lacking acinar Orai1 exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death. While digestive enzyme supplementation was ineffective, treatments constraining bacterial outgrowth (purified liquid diet, broad-spectrum antibiotics) rescued survival, feeding, and weight gain. Pancreatic levels of cathelicidin-related antimicrobial peptide (CRAMP) were reduced, and supplement of synthetic CRAMP prevented intestinal disease. These findings reveal a critical role for antimicrobial pancreatic secretion in gut innate immunity. Twit Text FOAVip Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28273482 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28273482 #FOAvip English Wikipedia <ref>{{Cite pmid|28273482 }}</ref> Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity #MMPMID28273482 Ahuja M ; Schwartz DM ; Tandon M ; Son A ; Zeng M ; Swaim W ; Eckhaus M ; Hoffman V ; Cui Y ; Xiao B ; Worley PF ; Muallem S Cell Metab 2017[Mar]; 25 (3 ): 635-646 PMID28273482 show ga The gut microbiome participates in numerous physiologic functions and communicates intimately with the host immune system. Antimicrobial peptides are critical components of intestinal innate immunity. We report a prominent role for antimicrobials secreted by pancreatic acini in shaping the gut microbiome that is essential for intestinal innate immunity, barrier function, and survival. Deletion of the Ca(2+) channel Orai1 in pancreatic acini of adult mice resulted in 60%-70% mortality within 3 weeks. Despite robust activation of the intestinal innate immune response, mice lacking acinar Orai1 exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death. While digestive enzyme supplementation was ineffective, treatments constraining bacterial outgrowth (purified liquid diet, broad-spectrum antibiotics) rescued survival, feeding, and weight gain. Pancreatic levels of cathelicidin-related antimicrobial peptide (CRAMP) were reduced, and supplement of synthetic CRAMP prevented intestinal disease. These findings reveal a critical role for antimicrobial pancreatic secretion in gut innate immunity. |*Gastrointestinal Microbiome [MESH] |*Immunity, Innate [MESH] |Acinar Cells/*metabolism [MESH] |Animals [MESH] |Anti-Infective Agents/*metabolism [MESH] |Calcium Signaling [MESH] |Cell Death [MESH] |Exocytosis [MESH] |Gastrointestinal Tract/*immunology/*metabolism [MESH] |Gene Deletion [MESH] |Homeostasis [MESH] |Inflammation Mediators/metabolism [MESH] |Inflammation/pathology [MESH] |Intestines/microbiology/pathology [MESH] |Mice [MESH] |Microbial Viability [MESH] |ORAI1 Protein/deficiency/*metabolism [MESH] |Pancreas/*cytology [MESH]Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes th(epmc).pdf DeepDyve Pubget Overpricing