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10.1111/jcmm.13014 http://scihub22266oqcxt.onion/10.1111/jcmm.13014 C5345661!5345661!27862899     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (4): 711-9 Nephropedia Template TP {{tp|p=27862899|t=2017. Pro?apoptotic Noxa is involved in ablative focal irradiation?induced lung injury |pdf=|usr=}}{{27862899}} gab.com Text Pro apoptotic Noxa is involved in ablative focal irradiation induced lung injury JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27862899 #FOAvip Although lung injury including fibrosis is a well?documented side effect of lung irradiation, the mechanisms underlying its pathology are poorly understood. X?rays are known to cause apoptosis in the alveolar epithelial cells of irradiated lungs, which results in fibrosis due to the proliferation and differentiation of fibroblasts and the deposition of collagen. Apoptosis and BH3?only pro?apoptotic proteins have been implicated in the pathogenesis of pulmonary fibrosis. Recently, we have established a clinically analogous experimental model that reflects focal high?dose irradiation of the ipsilateral lung. The goal of this study was to elucidate the mechanism underlying radiation?induced lung injury based on this model. A radiation dose of 90 Gy was focally delivered to the left lung of C57BL/6 mice for 14 days. About 9 days after irradiation, the mice began to show increased levels of the pro?apoptotic protein Noxa in the irradiated lung alongside increased apoptosis and fibrosis. Suppression of Noxa expression by small interfering RNA protected cells from radiation?induced cell death and decreased expression of fibrogenic markers. Furthermore, we showed that reactive oxygen species participate in Noxa?mediated, radiation?induced cell death. Taken together, our results show that Noxa is involved in X?ray?induced lung injury. Twit Text FOAVip Pro apoptotic Noxa is involved in ablative focal irradiation induced lung injury ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27862899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27862899 #FOAvip English Wikipedia <ref>{{Cite pmid|27862899}}</ref> Pro?apoptotic Noxa is involved in ablative focal irradiation?induced lung injury #MMPMID27862899 Kim J; An Y; Choi WH; Kim J; Cho S; Yoo BR; Kang JW; Lee Y; Lee Y; Cho J J Cell Mol Med 2017[Apr]; 21 (4): 711-9 PMID27862899show ga Although lung injury including fibrosis is a well?documented side effect of lung irradiation, the mechanisms underlying its pathology are poorly understood. X?rays are known to cause apoptosis in the alveolar epithelial cells of irradiated lungs, which results in fibrosis due to the proliferation and differentiation of fibroblasts and the deposition of collagen. Apoptosis and BH3?only pro?apoptotic proteins have been implicated in the pathogenesis of pulmonary fibrosis. Recently, we have established a clinically analogous experimental model that reflects focal high?dose irradiation of the ipsilateral lung. The goal of this study was to elucidate the mechanism underlying radiation?induced lung injury based on this model. A radiation dose of 90 Gy was focally delivered to the left lung of C57BL/6 mice for 14 days. About 9 days after irradiation, the mice began to show increased levels of the pro?apoptotic protein Noxa in the irradiated lung alongside increased apoptosis and fibrosis. Suppression of Noxa expression by small interfering RNA protected cells from radiation?induced cell death and decreased expression of fibrogenic markers. Furthermore, we showed that reactive oxygen species participate in Noxa?mediated, radiation?induced cell death. Taken together, our results show that Noxa is involved in X?ray?induced lung injury. äPro?apoptotic Noxa is involved in ablative focal irradiation?induced l(epmc).pdf DeepDyve Pubget Overpricing