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10.1111/jcmm.13015 http://scihub22266oqcxt.onion/10.1111/jcmm.13015 C5345631!5345631!27862996     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (4): 720-34 Nephropedia Template TP {{tp|p=27862996|t=2017. Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells |pdf=|usr=}}{{27862996}} gab.com Text Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27862996 #FOAvip Tannic acid (TA), a naturally occurring polyphenol, is a potent anti?oxidant with anti?proliferative effects on multiple cancers. However, its ability to modulate gene?specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism of TA to regulate canonical and non?canonical STAT pathways to impose the gene?specific induction of G1?arrest and apoptosis. Regardless of the p53 status and membrane receptors, TA induced G1?arrest and apoptosis in breast cancer cells. Tannic acid distinctly modulated both canonical and non?canonical STAT pathways, each with a specific role in TA?induced anti?cancer effects. Tannic acid enhanced STAT1 ser727 phosphorylation via upstream serine kinase p38. This STAT1 ser727 phosphorylation enhanced the DNA?binding activity of STAT1 and in turn enhanced expression of p21Waf1/Cip1. However, TA binds to EGF?R and inhibits the tyrosine phosphorylation of both STAT1 and STAT3. This inhibition leads to the inhibition of STAT3/BCL?2 DNA?binding activity. As a result, the expression and mitochondrial localization of BCl?2 are declined. This altered expression and localization of mitochondrial anti?pore factors resulted in the release of cytochrome c and the activation of intrinsic apoptosis cascade involving caspases. Taken together, our results suggest that TA modulates EGF?R/Jak2/STAT1/3 and P38/STAT1/p21Waf1/Cip1 pathways and induce G1?arrest and intrinsic apoptosis in breast carcinomas. Twit Text FOAVip Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27862996 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27862996 #FOAvip English Wikipedia <ref>{{Cite pmid|27862996}}</ref> Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells #MMPMID27862996 Darvin P; Joung YH; Kang DY; Sp N; Byun HJ; Hwang TS; Sasidharakurup H; Lee CH; Cho KH; Park KD; Lee HK; Yang YM J Cell Mol Med 2017[Apr]; 21 (4): 720-34 PMID27862996show ga Tannic acid (TA), a naturally occurring polyphenol, is a potent anti?oxidant with anti?proliferative effects on multiple cancers. However, its ability to modulate gene?specific expression of tumour suppressor genes and oncogenes has not been assessed. This work investigates the mechanism of TA to regulate canonical and non?canonical STAT pathways to impose the gene?specific induction of G1?arrest and apoptosis. Regardless of the p53 status and membrane receptors, TA induced G1?arrest and apoptosis in breast cancer cells. Tannic acid distinctly modulated both canonical and non?canonical STAT pathways, each with a specific role in TA?induced anti?cancer effects. Tannic acid enhanced STAT1 ser727 phosphorylation via upstream serine kinase p38. This STAT1 ser727 phosphorylation enhanced the DNA?binding activity of STAT1 and in turn enhanced expression of p21Waf1/Cip1. However, TA binds to EGF?R and inhibits the tyrosine phosphorylation of both STAT1 and STAT3. This inhibition leads to the inhibition of STAT3/BCL?2 DNA?binding activity. As a result, the expression and mitochondrial localization of BCl?2 are declined. This altered expression and localization of mitochondrial anti?pore factors resulted in the release of cytochrome c and the activation of intrinsic apoptosis cascade involving caspases. Taken together, our results suggest that TA modulates EGF?R/Jak2/STAT1/3 and P38/STAT1/p21Waf1/Cip1 pathways and induce G1?arrest and intrinsic apoptosis in breast carcinomas. äTannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling ax(epmc).pdf DeepDyve Pubget Overpricing