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10.1080/20013078.2017.1284449 http://scihub22266oqcxt.onion/10.1080/20013078.2017.1284449 C5345581!5345581!28326169     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28326169.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Extracell+Vesicles 2017 ; 6 (1): ä Nephropedia Template TP {{tp|p=28326169|t=2017. Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet?s disease severity |pdf=|usr=}}{{28326169}} gab.com Text Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet s disease severity JO: J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=28326169 #FOAvip Behçet?s disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) to immune cells, thereby leading to enhanced immune activation aggravating BD pathology. Notably, disease activity was correlated with elevated levels of circulating LL37 and EV plasma concentration. Stimulation of healthy PBMC with active BD patient EVs induced heightened IL1?, IFN?, IL6 and IP10 secretion compared to healthy and inactive BD EVs. Remarkably, when mixed with LL37, healthy plasma-EVs triggered a robust immune activation replicating the pathology inducing properties of BD EVs. The findings of this study could be of clinical interest in the management of BD, implicating LL37/EV association as one of the major contributors of BD pathogenesis.Abbreviations: BD: Behçet?s disease; EV: extracellular vesicle; BB: binding buffer; AnV: annexin V; autologEV: autologous extracellular vesicles; alloEV: allogeneic extracellular vesicles Twit Text FOAVip Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet s disease severity ????J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=28326169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28326169 #FOAvip English Wikipedia <ref>{{Cite pmid|28326169}}</ref> Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet?s disease severity #MMPMID28326169 Kahraman T; Gucluler G; Simsek I; Yagci FC; Yildirim M; Ozen C; Dinc A; Gursel M; Ikromzoda L; Sutlu T; Gay S; Gursel I J Extracell Vesicles 2017[]; 6 (1): ä PMID28326169show ga Behçet?s disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) to immune cells, thereby leading to enhanced immune activation aggravating BD pathology. Notably, disease activity was correlated with elevated levels of circulating LL37 and EV plasma concentration. Stimulation of healthy PBMC with active BD patient EVs induced heightened IL1?, IFN?, IL6 and IP10 secretion compared to healthy and inactive BD EVs. Remarkably, when mixed with LL37, healthy plasma-EVs triggered a robust immune activation replicating the pathology inducing properties of BD EVs. The findings of this study could be of clinical interest in the management of BD, implicating LL37/EV association as one of the major contributors of BD pathogenesis.Abbreviations: BD: Behçet?s disease; EV: extracellular vesicle; BB: binding buffer; AnV: annexin V; autologEV: autologous extracellular vesicles; alloEV: allogeneic extracellular vesicles äCirculating LL37 targets plasma extracellular vesicles to immune cells(epmc).pdf DeepDyve Pubget Overpricing