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10.1111/bph.13721 http://scihub22266oqcxt.onion/10.1111/bph.13721 C5345550!5345550 !28099680     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28099680 &cmd=llinks): Failed to open stream: HTTP request failed! 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Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature |pdf=|usr=}}{{28099680 }} gab.com Text Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28099680 #FOAvip Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure following the pathological remodelling of small pulmonary arteries. An increase in right ventricular (RV) afterload results in RV hypertrophy and RV failure. The pathophysiology of PH, and RV remodelling in particular, is not well understood, thus explaining, at least in part, why current PH therapies have a limited effect. Existing therapies mostly target the pulmonary circulation. Because the remodelled RV fails to support normal cardiac function, patients eventually succumb from RV failure. Developing novel therapies that directly target the function of the RV may therefore benefit patients with PH. In the past decade, several promising studies have investigated novel cardioprotective strategies in experimental models of PH. This review aims to comprehensively discuss and highlight these novel experimental approaches to confer, in the long-term, greater health benefit in patients with PH. Twit Text FOAVip Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28099680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28099680 #FOAvip English Wikipedia <ref>{{Cite pmid|28099680 }}</ref> Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature #MMPMID28099680 Maarman GJ ; Schulz R ; Sliwa K ; Schermuly RT ; Lecour S Br J Pharmacol 2017[Apr]; 174 (7 ): 497-511 PMID28099680 show ga Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure following the pathological remodelling of small pulmonary arteries. An increase in right ventricular (RV) afterload results in RV hypertrophy and RV failure. The pathophysiology of PH, and RV remodelling in particular, is not well understood, thus explaining, at least in part, why current PH therapies have a limited effect. Existing therapies mostly target the pulmonary circulation. Because the remodelled RV fails to support normal cardiac function, patients eventually succumb from RV failure. Developing novel therapies that directly target the function of the RV may therefore benefit patients with PH. In the past decade, several promising studies have investigated novel cardioprotective strategies in experimental models of PH. This review aims to comprehensively discuss and highlight these novel experimental approaches to confer, in the long-term, greater health benefit in patients with PH. |Animals [MESH] |Humans [MESH] |Hypertension, Pulmonary/*complications/*drug therapy [MESH] |Hypertrophy, Right Ventricular/*complications/*drug therapy [MESH]Novel putative pharmacological therapies to protect the right ventricl(epmc).pdf DeepDyve Pubget Overpricing