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10.1038/srep44184 http://scihub22266oqcxt.onion/10.1038/srep44184 C5345102!5345102!28281692     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28281692|t=2017. Ibuprofen results in alterations of human fetal testis development |pdf=|usr=}}{{28281692}} gab.com Text Ibuprofen results in alterations of human fetal testis development JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28281692 #FOAvip Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7?17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8?9?GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3. Testosterone was not suppressed in testes from fetuses younger than 8?GW, older than 10?12?GW, or in second trimester xenografted testes (14?17?GW). Ex vivo, ibuprofen also affected Sertoli cell by suppressing AMH production and mRNA expression of AMH, SOX9, DHH, and COL2A1. While PGE2 production was suppressed by ibuprofen, PGD2 production was not. Germ cell transcripts POU5F1, TFAP2C, LIN28A, ALPP and KIT were also reduced by ibuprofen. We conclude that, at concentrations relevant to human exposure and within a particular narrow ?early window? of sensitivity within first trimester, ibuprofen causes direct endocrine disturbances in the human fetal testis and alteration of the germ cell biology. Twit Text FOAVip Ibuprofen results in alterations of human fetal testis development ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28281692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28281692 #FOAvip English Wikipedia <ref>{{Cite pmid|28281692}}</ref> Ibuprofen results in alterations of human fetal testis development #MMPMID28281692 Ben Maamar M; Lesné L; Hennig K; Desdoits-Lethimonier C; Kilcoyne KR; Coiffec I; Rolland AD; Chevrier C; Kristensen DM; Lavoué V; Antignac JP; Le Bizec B; Dejucq-Rainsford N; Mitchell RT; Mazaud-Guittot S; Jégou B Sci Rep 2017[]; 7 (ä): ä PMID28281692show ga Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7?17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8?9?GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3. Testosterone was not suppressed in testes from fetuses younger than 8?GW, older than 10?12?GW, or in second trimester xenografted testes (14?17?GW). Ex vivo, ibuprofen also affected Sertoli cell by suppressing AMH production and mRNA expression of AMH, SOX9, DHH, and COL2A1. While PGE2 production was suppressed by ibuprofen, PGD2 production was not. Germ cell transcripts POU5F1, TFAP2C, LIN28A, ALPP and KIT were also reduced by ibuprofen. We conclude that, at concentrations relevant to human exposure and within a particular narrow ?early window? of sensitivity within first trimester, ibuprofen causes direct endocrine disturbances in the human fetal testis and alteration of the germ cell biology. äIbuprofen results in alterations of human fetal testis development (epmc).pdf DeepDyve Pubget Overpricing