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10.1038/ncomms14632 http://scihub22266oqcxt.onion/10.1038/ncomms14632 C5344980!5344980 !28272405     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28272405 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14632 Nephropedia Template TP {{tp|p=28272405 |t=2017. PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR |pdf=|usr=}}{{28272405 }} gab.com Text PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28272405 #FOAvip Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-ADP-ribose polymerase 1 (PARP1), whose role in gene transcription modulation has been well established. Here we show that, in response to LPS exposure, PARP1 interacts with the adenylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human antigen R (HuR), resulting in its PARylation, primarily at site D226. PARP inhibition and the D226 mutation impair HuR's PARylation, nucleocytoplasmic shuttling and mRNA binding. Increases in mRNA level or stability of pro-inflammatory cytokines/chemokines are abolished by PARP1 ablation or inhibition, or blocked in D226A HuR-expressing cells. The present study demonstrates a mechanism to regulate gene expression at the post-transcriptional level, and suggests that blocking the interaction of PARP1 with HuR could be a strategy to treat inflammation-related diseases that involve increased mRNA stability. Twit Text FOAVip PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28272405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28272405 #FOAvip English Wikipedia <ref>{{Cite pmid|28272405 }}</ref> PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR #MMPMID28272405 Ke Y ; Han Y ; Guo X ; Wen J ; Wang K ; Jiang X ; Tian X ; Ba X ; Boldogh I ; Zeng X Nat Commun 2017[Mar]; 8 (ä): 14632 PMID28272405 show ga Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-ADP-ribose polymerase 1 (PARP1), whose role in gene transcription modulation has been well established. Here we show that, in response to LPS exposure, PARP1 interacts with the adenylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human antigen R (HuR), resulting in its PARylation, primarily at site D226. PARP inhibition and the D226 mutation impair HuR's PARylation, nucleocytoplasmic shuttling and mRNA binding. Increases in mRNA level or stability of pro-inflammatory cytokines/chemokines are abolished by PARP1 ablation or inhibition, or blocked in D226A HuR-expressing cells. The present study demonstrates a mechanism to regulate gene expression at the post-transcriptional level, and suggests that blocking the interaction of PARP1 with HuR could be a strategy to treat inflammation-related diseases that involve increased mRNA stability. |*Gene Expression Regulation [MESH] |Animals [MESH] |Chemokines/immunology [MESH] |Cytokines/immunology [MESH] |ELAV-Like Protein 1/*genetics/immunology/metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Inflammation/*genetics/immunology [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophages, Peritoneal/drug effects/*immunology [MESH] |Mice [MESH] |Mutation [MESH] |Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors/*genetics/immunology [MESH] |Poly ADP Ribosylation [MESH] |Poly(ADP-ribose) Polymerase Inhibitors/pharmacology [MESH] |Protein Processing, Post-Translational/*genetics [MESH] |Protein Transport [MESH] |RAW 264.7 Cells [MESH] |RNA, Messenger/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH]PARP1 promotes gene expression at the post-transcriptiona level by mod(epmc).pdf DeepDyve Pubget Overpricing