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10.1038/ncomms14631 http://scihub22266oqcxt.onion/10.1038/ncomms14631 C5344303!5344303 !28266498     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28266498 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14631 Nephropedia Template TP {{tp|p=28266498 |t=2017. Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis |pdf=|usr=}}{{28266498 }} gab.com Text Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28266498 #FOAvip Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in growth-essential pathways. However, efficacy of virulence-linked targets may be affected by the contribution of virulence-related genes to metabolism. We evaluate the complex interrelationships between growth and virulence-linked pathways using a genome-scale metabolic network reconstruction of Pseudomonas aeruginosa strain PA14 and an updated, expanded reconstruction of P. aeruginosa strain PAO1. The PA14 reconstruction accounts for the activity of 112 virulence-linked genes and virulence factor synthesis pathways that produce 17 unique compounds. We integrate eight published genome-scale mutant screens to validate gene essentiality predictions in rich media, contextualize intra-screen discrepancies and evaluate virulence-linked gene distribution across essentiality datasets. Computational screening further elucidates interconnectivity between inhibition of virulence factor synthesis and growth. Successful validation of selected gene perturbations using PA14 transposon mutants demonstrates the utility of model-driven screening of therapeutic targets. Twit Text FOAVip Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28266498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266498 #FOAvip English Wikipedia <ref>{{Cite pmid|28266498 }}</ref> Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis #MMPMID28266498 Bartell JA ; Blazier AS ; Yen P ; Thøgersen JC ; Jelsbak L ; Goldberg JB ; Papin JA Nat Commun 2017[Mar]; 8 (ä): 14631 PMID28266498 show ga Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that may be associated with less potential for resistance than targets in growth-essential pathways. However, efficacy of virulence-linked targets may be affected by the contribution of virulence-related genes to metabolism. We evaluate the complex interrelationships between growth and virulence-linked pathways using a genome-scale metabolic network reconstruction of Pseudomonas aeruginosa strain PA14 and an updated, expanded reconstruction of P. aeruginosa strain PAO1. The PA14 reconstruction accounts for the activity of 112 virulence-linked genes and virulence factor synthesis pathways that produce 17 unique compounds. We integrate eight published genome-scale mutant screens to validate gene essentiality predictions in rich media, contextualize intra-screen discrepancies and evaluate virulence-linked gene distribution across essentiality datasets. Computational screening further elucidates interconnectivity between inhibition of virulence factor synthesis and growth. Successful validation of selected gene perturbations using PA14 transposon mutants demonstrates the utility of model-driven screening of therapeutic targets. |*Metabolic Networks and Pathways [MESH] |Biomass [MESH] |Culture Media [MESH] |Genes, Bacterial [MESH] |Genes, Essential [MESH] |Models, Biological [MESH] |Mutation/genetics [MESH] |Oligopeptides/biosynthesis [MESH] |Pseudomonas aeruginosa/genetics/growth & development/*metabolism/*pathogenicity [MESH] |Reproducibility of Results [MESH] |Small Molecule Libraries/metabolism [MESH] |Virulence Factors/*biosynthesis [MESH]Reconstruction of the metabolic network of Pseudomonas aeruginosa to i(epmc).pdf DeepDyve Pubget Overpricing