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10.1038/cdd.2016.136 http://scihub22266oqcxt.onion/10.1038/cdd.2016.136 C5344204!5344204!28009350     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2017 ; 24 (3): 421-32 Nephropedia Template TP {{tp|p=28009350|t=2017. HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer |pdf=|usr=}}{{28009350}} gab.com Text HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28009350 #FOAvip MicroRNAs (miRNAs) have emerged as a major regulator of the initiation and progression of human cancers, including breast cancer. However, the cooperative effects and transcriptional regulation of multiple miRNAs, especially miRNAs that are present in clusters, remain largely undiscovered. Here we showed that all members of the miR-23~27~24 clusters are upregulated and function as oncogenes in breast cancer and simultaneously target HIC1. Furthermore, we found that HIC1 functions as a transcriptional repressor to negatively control the expression of miR-23~27~24 clusters and forms a double-negative (overall positive) feedback loop. This feedback regulatory pathway is important because overexpression of miR-23~27~24 clusters can remarkably accelerate tumor growth, whereas restoration of HIC1 significantly blocks tumor growth in vivo. A mathematical model was created to quantitatively illustrate the regulatory circuit. Our finding highlights the cooperative effects of miRNAs in a cluster and adds another layer of complexity to the miRNA regulatory network. This study may also provide insight into the molecular mechanisms of breast cancer progression. Twit Text FOAVip HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=28009350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28009350 #FOAvip English Wikipedia <ref>{{Cite pmid|28009350}}</ref> HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer #MMPMID28009350 Wang Y; Liang H; Zhou G; Hu X; Liu Z; Jin F; Yu M; Sang J; Zhou Y; Fu Z; Zhang CY; Zhang W; Zen K; Chen X Cell Death Differ 2017[Mar]; 24 (3): 421-32 PMID28009350show ga MicroRNAs (miRNAs) have emerged as a major regulator of the initiation and progression of human cancers, including breast cancer. However, the cooperative effects and transcriptional regulation of multiple miRNAs, especially miRNAs that are present in clusters, remain largely undiscovered. Here we showed that all members of the miR-23~27~24 clusters are upregulated and function as oncogenes in breast cancer and simultaneously target HIC1. Furthermore, we found that HIC1 functions as a transcriptional repressor to negatively control the expression of miR-23~27~24 clusters and forms a double-negative (overall positive) feedback loop. This feedback regulatory pathway is important because overexpression of miR-23~27~24 clusters can remarkably accelerate tumor growth, whereas restoration of HIC1 significantly blocks tumor growth in vivo. A mathematical model was created to quantitatively illustrate the regulatory circuit. Our finding highlights the cooperative effects of miRNAs in a cluster and adds another layer of complexity to the miRNA regulatory network. This study may also provide insight into the molecular mechanisms of breast cancer progression. äHIC1 and miR-23~27~24 clusters form a double-negative feedback loop in(epmc).pdf DeepDyve Pubget Overpricing