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10.1161/HYPERTENSIONAHA.116.08620

http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.116.08620
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suck abstract from ncbi


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pmid28167687
      Hypertension 2017 ; 69 (4 ): 731-738
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  • Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio: A Prospective Cohort Study of Unselected Nulliparous Women #MMPMID28167687
  • Sovio U ; Gaccioli F ; Cook E ; Hund M ; Charnock-Jones DS ; Smith GC
  • Hypertension 2017[Apr]; 69 (4 ): 731-738 PMID28167687 show ga
  • We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 platform at ?20, ?28, and ?36 weeks of gestational age (wkGA). Screen positive was defined as an sFlt-1:PlGF ratio >38, but higher thresholds were also studied. At 28 wkGA, an sFlt-1:PlGF ratio >38 had a positive predictive value (PPV) of 32% for preeclampsia and preterm birth, and the PPV was similar comparing women with low and high prior risk of disease. At 36 wkGA, an sFlt-1:PlGF ratio >38 had a PPV for severe preeclampsia of 20% in high-risk women and 6.4% in low-risk women. At 36 wkGA, an sFlt-1:PlGF ratio >110 had a PPV of 30% for severe preeclampsia, and the PPV was similar comparing low- and high-risk women. Overall, at 36 wkGA, 195 (5.2%) women either had an sFlt-1:PlGF ratio of >110 or an sFlt-1:PlGF ratio >38 plus maternal risk factors: 43% of these women developed preeclampsia, about half with severe features. Among low-risk women at 36 wkGA, an sFlt-1:PlGF ratio ?38 had a negative predictive value for severe preeclampsia of 99.2%. The sFlt-1:PlGF ratio provided clinically useful prediction of the risk of the most important manifestations of preeclampsia in a cohort of unselected nulliparous women.
  • |*Parity [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Biomarkers/blood [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Gestational Age [MESH]
  • |Humans [MESH]
  • |Placenta Growth Factor/*blood [MESH]
  • |Pre-Eclampsia/*blood/diagnosis [MESH]
  • |Predictive Value of Tests [MESH]
  • |Pregnancy [MESH]
  • |Pregnancy Outcome [MESH]
  • |Pregnancy Trimester, Second [MESH]
  • |Pregnancy Trimester, Third [MESH]
  • |Prospective Studies [MESH]
  • |ROC Curve [MESH]
  • |Risk Factors [MESH]
  • |Vascular Endothelial Growth Factor Receptor-1/*blood [MESH]


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