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10.3390/ijms18020460 http://scihub22266oqcxt.onion/10.3390/ijms18020460 C5343993!5343993 !28230774     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28230774 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (2 ): ä Nephropedia Template TP {{tp|p=28230774 |t=2017. Inhibition of CCAR1, a Coactivator of ?-Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells |pdf=|usr=}}{{28230774 }} gab.com Text Inhibition of CCAR1, a Coactivator of -Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28230774 #FOAvip The aberrant activation of Wnt signaling has been implicated in a variety of human cancers, including gastric cancer. Given the current hypothesis that cancer arises from cancer stem cells (CSCs), targeting the critical signaling pathways that support CSC self-renewal appears to be a useful approach for cancer therapy. Cell cycle and apoptosis regulator 1 (CCAR1) is a transcriptional coactivator which has been shown to be a component of Wnt/?-catenin signaling, and which plays an important role in transcriptional regulation by ?-catenin. However, the function and clinical significance of CCAR1 in gastric cancer have not been elucidated. Here, we show that elevated CCAR1 nuclear expression correlates with the occurrence of gastric cancer. In addition, RNAi-mediated CCAR1 reduction not only suppressed the cell growth and increased apoptosis in AGS and MKN28 cells, but also reduced the migration and invasion ability of these cells. Furthermore, an in vivo xenograft assay revealed that the expression level of CCAR1 was critical for tumorigenesis. Our data demonstrates that CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells. Moreover, CCAR1 may serve as a diagnostic marker and a potential therapeutic target. Twit Text FOAVip Inhibition of CCAR1, a Coactivator of -Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28230774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230774 #FOAvip English Wikipedia <ref>{{Cite pmid|28230774 }}</ref> Inhibition of CCAR1, a Coactivator of ?-Catenin, Suppresses the Proliferation and Migration of Gastric Cancer Cells #MMPMID28230774 Chang TS ; Wei KL ; Lu CK ; Chen YH ; Cheng YT ; Tung SY ; Wu CS ; Chiang MK Int J Mol Sci 2017[Feb]; 18 (2 ): ä PMID28230774 show ga The aberrant activation of Wnt signaling has been implicated in a variety of human cancers, including gastric cancer. Given the current hypothesis that cancer arises from cancer stem cells (CSCs), targeting the critical signaling pathways that support CSC self-renewal appears to be a useful approach for cancer therapy. Cell cycle and apoptosis regulator 1 (CCAR1) is a transcriptional coactivator which has been shown to be a component of Wnt/?-catenin signaling, and which plays an important role in transcriptional regulation by ?-catenin. However, the function and clinical significance of CCAR1 in gastric cancer have not been elucidated. Here, we show that elevated CCAR1 nuclear expression correlates with the occurrence of gastric cancer. In addition, RNAi-mediated CCAR1 reduction not only suppressed the cell growth and increased apoptosis in AGS and MKN28 cells, but also reduced the migration and invasion ability of these cells. Furthermore, an in vivo xenograft assay revealed that the expression level of CCAR1 was critical for tumorigenesis. Our data demonstrates that CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells. Moreover, CCAR1 may serve as a diagnostic marker and a potential therapeutic target. |Aged [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins/genetics/*metabolism [MESH] |Apoptosis/genetics [MESH] |Cell Cycle Proteins/genetics/*metabolism [MESH] |Cell Cycle/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Heterografts [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Prognosis [MESH] |RNA Interference [MESH] |RNA, Small Interfering/genetics [MESH] |Stomach Neoplasms/genetics/*metabolism/mortality/pathology [MESH] |Wnt Signaling Pathway [MESH]Inhibition of CCAR1, a Coactivator of ?-Catenin, Suppresses the Prolif(epmc).pdf DeepDyve Pubget Overpricing