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10.3390/ijms18020390 http://scihub22266oqcxt.onion/10.3390/ijms18020390 C5343925!5343925 !28208683     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28208683 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (2 ): ä Nephropedia Template TP {{tp|p=28208683 |t=2017. Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-?1/Smads Signal Transduction Pathway in IgA Nephropathy |pdf=|usr=}}{{28208683 }} gab.com Text Plasma Gelsolin Induced Glomerular Fibrosis via the TGF- 1/Smads Signal Transduction Pathway in IgA Nephropathy JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28208683 #FOAvip Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-?1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-?1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs) show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1) from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-?1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-?1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-?1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients. Twit Text FOAVip Plasma Gelsolin Induced Glomerular Fibrosis via the TGF- 1/Smads Signal Transduction Pathway in IgA Nephropathy ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28208683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28208683 #FOAvip English Wikipedia <ref>{{Cite pmid|28208683 }}</ref> Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-?1/Smads Signal Transduction Pathway in IgA Nephropathy #MMPMID28208683 Zhang L ; Han C ; Ye F ; He Y ; Jin Y ; Wang T ; Wu Y ; Jiang Y ; Zhang F ; Jin X Int J Mol Sci 2017[Feb]; 18 (2 ): ä PMID28208683 show ga Glomerular fibrosis has been shown to be closely related to the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular fibrosis remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in the serum of an IgAN mouse model and that pGSN deposition was found in the glomeruli. Another cytokine, TGF-?1, which is closely related to glomerular fibrosis, was also found to be highly expressed in the glomeruli. In the present study, we report that pGSN induces glomerular fibrosis through the TGF-?1/Smads signal transduction pathway. This is supported by the following findings: human mesangial cells (HMCs) show remarkable morphological changes and proliferation in response to co-stimulation with pGSN and polymeric IgA1 (pIgA1) from IgAN patients compared to other controls. Moreover, ELISA assays showed that more TGF-?1 secretion was found in HMCs supernatants in the co-stimulation group. Further experiments showed increased TGF-?1, Smad3, p-Smad2/3, Smad4, and collagen 1 and decreased Smad7 expression in the co-stimulation group. Our present study implied that the synergistic effect of pGSN and pIgA induced glomerular fibrosis via the TGF-?1/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients. |*Signal Transduction [MESH] |Biomarkers [MESH] |Case-Control Studies [MESH] |Cell Proliferation [MESH] |Fibrosis [MESH] |Fluorescent Antibody Technique [MESH] |Gelsolin/*blood [MESH] |Glomerulonephritis, IGA/etiology/*metabolism/*pathology [MESH] |Humans [MESH] |Mesangial Cells/metabolism/pathology/ultrastructure [MESH] |Smad Proteins/*metabolism [MESH]Plasma Gelsolin Induced Glomerular Fibrosis via the TGF-?1/Smads Signa(epmc).pdf DeepDyve Pubget Overpricing