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10.3390/ijms18020236 http://scihub22266oqcxt.onion/10.3390/ijms18020236 C5343774!5343774 !28125014     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28125014 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway |pdf=|usr=}}{{28125014 }} gab.com Text Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28125014 #FOAvip 5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as 5-hydroxyeicosatetraenoic acid (5-HETE) and a number of leukotrienes are mostly derived from arachidonic acid and have been shown to be lipid mediators of inflammation in different pathological states including cancer. Upregulated 5-lipoxygenase expression and metabolite production is found in a number of cancer types and has been shown to be associated with increased tumorigenesis. 5-lipoxygenase activity is present in a number of diverse cell types of the immune system and connective tissue. In this review, we discuss potential routes through which cancer cells may utilise the 5-lipoxygenase pathway to interact with the tumour microenvironment during the development and progression of a tumour. Furthermore, immune-derived 5-lipoxygenase signalling can drive both pro- and anti-tumour effects depending on the immune cell subtype and an overview of evidence for these opposing effects is presented. Twit Text FOAVip Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28125014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28125014 #FOAvip English Wikipedia <ref>{{Cite pmid|28125014 }}</ref> Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway #MMPMID28125014 Moore GY ; Pidgeon GP Int J Mol Sci 2017[Jan]; 18 (2 ): ä PMID28125014 show ga 5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as 5-hydroxyeicosatetraenoic acid (5-HETE) and a number of leukotrienes are mostly derived from arachidonic acid and have been shown to be lipid mediators of inflammation in different pathological states including cancer. Upregulated 5-lipoxygenase expression and metabolite production is found in a number of cancer types and has been shown to be associated with increased tumorigenesis. 5-lipoxygenase activity is present in a number of diverse cell types of the immune system and connective tissue. In this review, we discuss potential routes through which cancer cells may utilise the 5-lipoxygenase pathway to interact with the tumour microenvironment during the development and progression of a tumour. Furthermore, immune-derived 5-lipoxygenase signalling can drive both pro- and anti-tumour effects depending on the immune cell subtype and an overview of evidence for these opposing effects is presented. |*Cell Communication [MESH] |*Signal Transduction [MESH] |*Tumor Microenvironment/immunology [MESH] |Adipose Tissue/immunology/metabolism [MESH] |Animals [MESH] |Arachidonate 5-Lipoxygenase/*metabolism [MESH] |Biosynthetic Pathways/drug effects [MESH] |Cyclooxygenase 2/metabolism [MESH] |Fibroblasts/immunology/metabolism/pathology [MESH] |Humans [MESH] |Immunomodulation [MESH] |Leukotrienes/biosynthesis [MESH] |Lipid Metabolism [MESH] |Lymphocytes/immunology/metabolism [MESH] |Myeloid Cells/immunology/metabolism [MESH] |Neoplasms/immunology/*metabolism/*pathology [MESH] |Neovascularization, Pathologic/immunology/metabolism [MESH]Cross-Talk between Cancer Cells and the Tumour Microenvironment: The R(epmc).pdf DeepDyve Pubget Overpricing