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10.1590/1414-431X20165637 http://scihub22266oqcxt.onion/10.1590/1414-431X20165637 C5343560!5343560!28225866     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28225866&cmd=llinks): Failed to open stream: HTTP request failed! 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Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia |pdf=|usr=}}{{28225866}} gab.com Text Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia JO: Braz J Med Biol Res http://www.kidney.de/pget.php?&tw=1&pmid=28225866 #FOAvip Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed. Myeloid-derived suppressor cells (MDSCs) are other immunosuppressive cells, which can also suppress T cell activation by secreting arginase, iNOS and ROS, and are essential for Treg cells? differentiation and maturation. Therefore, we speculate that MDSCs might also be involved in the immune-dysregulation mechanism of ITP. In this study, we tested MDSCs and Treg cells in peripheral blood samples of twenty-five ITP patients and ten healthy donors. We found that MDSCs and Treg cells decreased simultaneously in active ITP patients. Relapsed ITP patients showed lower MDSCs levels compared with new patients. All patients received immunosuppressive treatment including dexamethasone alone or in combination with intravenous immune globulin. We found that MDSCs? level after treatment correlated with platelet recovery. Our study is the first that focused on MDSCs? role in ITP. Based on our results, we concluded that circulating MDSCs could predict disease activity and treatment response in ITP patients. This preliminary conclusion indicates a substantial significance of MDSCs in the pathophysiology and clinical treatment of ITP, which deserves further investigation. Twit Text FOAVip Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia ????Braz J Med Biol Res http://www.kidney.de/pget.php?&tw=1&pmid=28225866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28225866 #FOAvip English Wikipedia <ref>{{Cite pmid|28225866}}</ref> Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia #MMPMID28225866 Zhou J; Zhou Y; Wen J; Sun X; Zhang X Braz J Med Biol Res 2017[]; 50 (2): ä PMID28225866show ga Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed. Myeloid-derived suppressor cells (MDSCs) are other immunosuppressive cells, which can also suppress T cell activation by secreting arginase, iNOS and ROS, and are essential for Treg cells? differentiation and maturation. Therefore, we speculate that MDSCs might also be involved in the immune-dysregulation mechanism of ITP. In this study, we tested MDSCs and Treg cells in peripheral blood samples of twenty-five ITP patients and ten healthy donors. We found that MDSCs and Treg cells decreased simultaneously in active ITP patients. Relapsed ITP patients showed lower MDSCs levels compared with new patients. All patients received immunosuppressive treatment including dexamethasone alone or in combination with intravenous immune globulin. We found that MDSCs? level after treatment correlated with platelet recovery. Our study is the first that focused on MDSCs? role in ITP. Based on our results, we concluded that circulating MDSCs could predict disease activity and treatment response in ITP patients. This preliminary conclusion indicates a substantial significance of MDSCs in the pathophysiology and clinical treatment of ITP, which deserves further investigation. äCirculating myeloid-derived suppressor cells predict disease activity (epmc).pdf DeepDyve Pubget Overpricing