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10.1126/science.aaf6756 http://scihub22266oqcxt.onion/10.1126/science.aaf6756 C5343513!5343513!27365313     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 353 (6295): 179-84 Nephropedia Template TP {{tp|p=27365313|t=2016. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease |pdf=|usr=}}{{27365313}} gab.com Text Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27365313 #FOAvip Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive. Here, we show that in the antibody-mediated autoimmune disease pemphigus vulgaris (PV), autoantigen-based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR). We engineered human T cells to express a chimeric autoantibody receptor (CAAR), consisting of the PV autoantigen, desmoglein (Dsg) 3, fused to CD137-CD3? signaling domains. Dsg3 CAAR-T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3-specific B cells in vivo. CAAR-T cells may provide an effective and universal strategy for specific targeting of autoreactive B cells in antibody-mediated autoimmune disease. Twit Text FOAVip Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27365313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27365313 #FOAvip English Wikipedia <ref>{{Cite pmid|27365313}}</ref> Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease #MMPMID27365313 Ellebrecht CT; Bhoj VG; Nace A; Choi EJ; Mao X; Cho MJ; Di Zenzo G; Lanzavecchia A; Seykora JT; Cotsarelis G; Milone MC; Payne AS Science 2016[Jul]; 353 (6295): 179-84 PMID27365313show ga Ideally, therapy for autoimmune diseases should eliminate pathogenic autoimmune cells while sparing protective immunity, but feasible strategies for such an approach have been elusive. Here, we show that in the antibody-mediated autoimmune disease pemphigus vulgaris (PV), autoantigen-based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR). We engineered human T cells to express a chimeric autoantibody receptor (CAAR), consisting of the PV autoantigen, desmoglein (Dsg) 3, fused to CD137-CD3? signaling domains. Dsg3 CAAR-T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3-specific B cells in vivo. CAAR-T cells may provide an effective and universal strategy for specific targeting of autoreactive B cells in antibody-mediated autoimmune disease. äReengineering chimeric antigen receptor T cells for targeted therapy o(epmc).pdf DeepDyve Pubget Overpricing