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10.1038/srep43718 http://scihub22266oqcxt.onion/10.1038/srep43718 C5343429!5343429!28276434     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28276434|t=2017. Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis |pdf=|usr=}}{{28276434}} gab.com Text Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28276434 #FOAvip Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby producing fragments with novel chemotactic activity. Furthermore, osteopontin reduces the release of proteasomes in the extracellular space. The latter phenomenon seems to occur in vivo in multiple sclerosis, where it reflects the remission/relapse alternation. The extracellular proteasome-mediated inflammatory pathway may represent a general mechanism to control inflammation in inflammatory diseases. Twit Text FOAVip Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28276434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28276434 #FOAvip English Wikipedia <ref>{{Cite pmid|28276434}}</ref> Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis #MMPMID28276434 Dianzani C; Bellavista E; Liepe J; Verderio C; Martucci M; Santoro A; Chiocchetti A; Luca Gigliotti C; Boggio E; Ferrara B; Riganti L; Keller C; Janek K; Niewienda A; Fenoglio C; Sorosina M; Cantello R; Kloetzel PM; Stumpf MPH; Paul F; Ruprecht K; Galimberti D; Martinelli Boneschi F; Comi C; Dianzani U; Mishto M Sci Rep 2017[]; 7 (ä): ä PMID28276434show ga Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-inflammatory activities. Here we show by in vitro experiments that secreted osteopontin can be processed by extracellular proteasomes, thereby producing fragments with novel chemotactic activity. Furthermore, osteopontin reduces the release of proteasomes in the extracellular space. The latter phenomenon seems to occur in vivo in multiple sclerosis, where it reflects the remission/relapse alternation. The extracellular proteasome-mediated inflammatory pathway may represent a general mechanism to control inflammation in inflammatory diseases. äExtracellular proteasome-osteopontin circuit regulates cell migration (epmc).pdf DeepDyve Pubget Overpricing