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10.1038/srep43949 http://scihub22266oqcxt.onion/10.1038/srep43949 C5343424!5343424 !28276453     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28276453 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 43949 Nephropedia Template TP {{tp|p=28276453 |t=2017. IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance |pdf=|usr=}}{{28276453 }} gab.com Text IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28276453 #FOAvip Restoring the contractile function of long-term denervated skeletal muscle (SKM) cells is difficult due to the long period of denervation, which causes a loss of contractility. Although sensory innervation is considered a promising protective approach, its effect is still restricted. In this study, we introduced insulin-like growth factor-1 (IGF-1) as an efficient protective agent and observed that IGF-1 potentiated the effects of sensory protection by preventing denervated muscle atrophy and improving the condition of denervated muscle cells in vivo and in vitro. IGF-1-induced Akt phosphorylation suppressed the mitochondrial outer-membrane protein Mul1 expression, which is a key step on preserving contractile property of sensory innervated SKM cells. Mul1 overexpression interfered with the balance between mitochondrial fusion and fission and was a key node for blocking the effects of IGF-1 that preserved the contractility of sensory-innervated SKM cells. Activation of AMP-activated protein kinase ? (AMPK?), a mitochondrial downstream target, could block the effects of IGF-1. These data provide novel evidence that might be applied when searching for new approaches to improve the functional condition of long-term denervated SKM cells by increasing sensory protection using the IGF-1 signalling system to modulate the balance between mitochondrial fusion and fission. Twit Text FOAVip IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28276453 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28276453 #FOAvip English Wikipedia <ref>{{Cite pmid|28276453 }}</ref> IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance #MMPMID28276453 Ding Y ; Li J ; Liu Z ; Liu H ; Li H ; Li Z Sci Rep 2017[Mar]; 7 (ä): 43949 PMID28276453 show ga Restoring the contractile function of long-term denervated skeletal muscle (SKM) cells is difficult due to the long period of denervation, which causes a loss of contractility. Although sensory innervation is considered a promising protective approach, its effect is still restricted. In this study, we introduced insulin-like growth factor-1 (IGF-1) as an efficient protective agent and observed that IGF-1 potentiated the effects of sensory protection by preventing denervated muscle atrophy and improving the condition of denervated muscle cells in vivo and in vitro. IGF-1-induced Akt phosphorylation suppressed the mitochondrial outer-membrane protein Mul1 expression, which is a key step on preserving contractile property of sensory innervated SKM cells. Mul1 overexpression interfered with the balance between mitochondrial fusion and fission and was a key node for blocking the effects of IGF-1 that preserved the contractility of sensory-innervated SKM cells. Activation of AMP-activated protein kinase ? (AMPK?), a mitochondrial downstream target, could block the effects of IGF-1. These data provide novel evidence that might be applied when searching for new approaches to improve the functional condition of long-term denervated SKM cells by increasing sensory protection using the IGF-1 signalling system to modulate the balance between mitochondrial fusion and fission. |*Mitochondrial Dynamics [MESH] |AMP-Activated Protein Kinases/metabolism [MESH] |Animals [MESH] |Atrophy [MESH] |Cell Line [MESH] |DNA, Mitochondrial/metabolism [MESH] |Ganglia, Spinal/*metabolism [MESH] |Insulin-Like Growth Factor I/*metabolism [MESH] |Male [MESH] |Mitochondria/metabolism/pathology [MESH] |Mitochondrial Proteins/metabolism [MESH] |Muscle Proteins [MESH] |Muscle, Skeletal/*innervation/*metabolism/pathology [MESH] |Proto-Oncogene Proteins c-akt [MESH] |Rats, Wistar [MESH] |SKP Cullin F-Box Protein Ligases [MESH] |Signal Transduction [MESH]IGF-1 potentiates sensory innervation signalling by modulating the mit(epmc).pdf DeepDyve Pubget Overpricing