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10.1111/cei.12917 http://scihub22266oqcxt.onion/10.1111/cei.12917 C5343361!5343361!28019655     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28019655&cmd=llinks): Failed to open stream: HTTP request failed! 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Tumour?activated liver stromal cells regulate myeloid?derived suppressor cells accumulation in the liver |pdf=|usr=}}{{28019655}} gab.com Text Tumour activated liver stromal cells regulate myeloid derived suppressor cells accumulation in the liver JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28019655 #FOAvip Regulating mechanisms underlying hepatic myeloid?derived suppressor cell (MDSC) accumulation remain to be described. Here, we provide evidence for the involvement of tumour?activated liver stromal cells in the process of hepatic MDSCs migration and accumulation. Our data showed an elevated frequency of MDSCs in the liver of tumour?bearing mice. Moreover, tumour?activated liver stromal cells promote MDSC migration into the liver site. Further investigation indicated higher levels of cytokine and chemokine expression in liver stromal cells after exposure to the tumour?conditioned supernatant. Notably, the expression levels of proinflammatory factors, mainly including macrophage colony stimulating factor (M?CSF), transforming growth factor?? (TGF??), monocyte chemotactic protein?1 (MCP?1) and stromal?derived factor?1 (SDF?1), increased after treatment with tumour?conditioned supernatant, and blockade of MCP?1 or SDF?1 decreased the proportion of tumour infiltrated MDSCs in mice co?transplanted with liver stromal cells and tumour cells, but not in mice with only tumour cells injection. These findings demonstrate that tumour?activated liver stromal cells produce higher levels of chemokines and cytokines, which may contribute to MDSC accumulation into the liver site in patients with liver cancer. Twit Text FOAVip Tumour activated liver stromal cells regulate myeloid derived suppressor cells accumulation in the liver ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28019655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28019655 #FOAvip English Wikipedia <ref>{{Cite pmid|28019655}}</ref> Tumour?activated liver stromal cells regulate myeloid?derived suppressor cells accumulation in the liver #MMPMID28019655 Zhang H; He G; Kong Y; Chen Y; Wang B; Sun X; Jia B; Xie X; Wang X; Chen D; Wei L; Zhang M; Zeng H; Chen H Clin Exp Immunol 2017[Apr]; 188 (1): 96-108 PMID28019655show ga Regulating mechanisms underlying hepatic myeloid?derived suppressor cell (MDSC) accumulation remain to be described. Here, we provide evidence for the involvement of tumour?activated liver stromal cells in the process of hepatic MDSCs migration and accumulation. Our data showed an elevated frequency of MDSCs in the liver of tumour?bearing mice. Moreover, tumour?activated liver stromal cells promote MDSC migration into the liver site. Further investigation indicated higher levels of cytokine and chemokine expression in liver stromal cells after exposure to the tumour?conditioned supernatant. Notably, the expression levels of proinflammatory factors, mainly including macrophage colony stimulating factor (M?CSF), transforming growth factor?? (TGF??), monocyte chemotactic protein?1 (MCP?1) and stromal?derived factor?1 (SDF?1), increased after treatment with tumour?conditioned supernatant, and blockade of MCP?1 or SDF?1 decreased the proportion of tumour infiltrated MDSCs in mice co?transplanted with liver stromal cells and tumour cells, but not in mice with only tumour cells injection. These findings demonstrate that tumour?activated liver stromal cells produce higher levels of chemokines and cytokines, which may contribute to MDSC accumulation into the liver site in patients with liver cancer. äTumour?activated liver stromal cells regulate myeloid?derived suppress(epmc).pdf DeepDyve Pubget Overpricing