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10.1111/cei.12901 http://scihub22266oqcxt.onion/10.1111/cei.12901 C5343353!5343353!27859022     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 310.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2017 ; 188 (1): 53-62 Nephropedia Template TP {{tp|p=27859022|t=2017. Immunoglobulin (Ig)G1 and IgG4 anti?cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti?CCP associates with smoking in patients with recent?onset rheumatoid arthritis (the Swedish TIRA project) |pdf=|usr=}}{{27859022}} gab.com Text Immunoglobulin (Ig)G1 and IgG4 anti cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti CCP associates with smoking in patients with recent onset rheumatoid arthritis (the Swedish TIRA project) JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27859022 #FOAvip Given the possible importance of anti?citrullinated peptide/protein antibodies (ACPA) for initiation and progression of rheumatoid arthritis (RA), extended knowledge about the different isotypes and subclasses is important. In the present study, we analysed the immunoglobulin (Ig)G subclasses regarding reactivity against cyclic citrullinated peptides (anti?CCP) among 504 clinically well?characterized patients with recent?onset RA in relation to smoking habits, shared epitope (SE) status and IgA and pan?IgG anti?CCP antibodies. All patients, regardless of pan?IgG anti?CCP status, were analysed for IgG1?4 CCP reactivity. Sixty?nine per cent were positive in any IgG anti?CCP subclass, and of these 67% tested positive regarding IgG1, 35% IgG2, 32% IgG3, and 59% IgG4 anti?CCP. Among ever?smokers the percentages of IgG2 anti?CCP (P?=?0·01) and IgA anti?CCP (P?=?0·002)?positive cases were significantly higher compared to never?smokers. A positive IgG anti?CCP subclass ?negative cases. Combining SE and smoking data revealed that IgG1 and IgG4 anti?CCP were the IgG anti?CCP isotypes associated with expression of SE, although the lower number of patients positive for IgG2 or IgG3 anti?CCP could, however, have influenced the results. High levels of IgG2 anti?CCP were shown to correlate with expression of the ?non?SE? allele human leucocyte antigen (HLA)?DRB1*15. In conclusion, in this study we describe different risk factor characteristics across the IgG anti?CCP subclasses, where IgG2 appears similar to IgA anti?CCP regarding the predominant association with smoking, while IgG1 and IgG4 related more distinctly to the carriage of SE genes. Twit Text FOAVip Immunoglobulin (Ig)G1 and IgG4 anti cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti CCP associates with smoking in patients with recent onset rheumatoid arthritis (the Swedish TIRA project) ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27859022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27859022 #FOAvip English Wikipedia <ref>{{Cite pmid|27859022}}</ref> Immunoglobulin (Ig)G1 and IgG4 anti?cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti?CCP associates with smoking in patients with recent?onset rheumatoid arthritis (the Swedish TIRA project) #MMPMID27859022 Martinsson K; Johansson A; Kastbom A; Skogh T Clin Exp Immunol 2017[Apr]; 188 (1): 53-62 PMID27859022show ga Given the possible importance of anti?citrullinated peptide/protein antibodies (ACPA) for initiation and progression of rheumatoid arthritis (RA), extended knowledge about the different isotypes and subclasses is important. In the present study, we analysed the immunoglobulin (Ig)G subclasses regarding reactivity against cyclic citrullinated peptides (anti?CCP) among 504 clinically well?characterized patients with recent?onset RA in relation to smoking habits, shared epitope (SE) status and IgA and pan?IgG anti?CCP antibodies. All patients, regardless of pan?IgG anti?CCP status, were analysed for IgG1?4 CCP reactivity. Sixty?nine per cent were positive in any IgG anti?CCP subclass, and of these 67% tested positive regarding IgG1, 35% IgG2, 32% IgG3, and 59% IgG4 anti?CCP. Among ever?smokers the percentages of IgG2 anti?CCP (P?=?0·01) and IgA anti?CCP (P?=?0·002)?positive cases were significantly higher compared to never?smokers. A positive IgG anti?CCP subclass ?negative cases. Combining SE and smoking data revealed that IgG1 and IgG4 anti?CCP were the IgG anti?CCP isotypes associated with expression of SE, although the lower number of patients positive for IgG2 or IgG3 anti?CCP could, however, have influenced the results. High levels of IgG2 anti?CCP were shown to correlate with expression of the ?non?SE? allele human leucocyte antigen (HLA)?DRB1*15. In conclusion, in this study we describe different risk factor characteristics across the IgG anti?CCP subclasses, where IgG2 appears similar to IgA anti?CCP regarding the predominant association with smoking, while IgG1 and IgG4 related more distinctly to the carriage of SE genes. äImmunoglobulin (Ig)G1 and IgG4 anti?cyclic citrullinated peptide (CCP)(epmc).pdf DeepDyve Pubget Overpricing