Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cei.12913 http://scihub22266oqcxt.onion/10.1111/cei.12913 C5343345!5343345!27936517     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2017 ; 188 (1): 79-85 Nephropedia Template TP {{tp|p=27936517|t=2017. Novel biomarkers for the assessment of paediatric systemic lupus erythematosus nephritis |pdf=|usr=}}{{27936517}} gab.com Text Novel biomarkers for the assessment of paediatric systemic lupus erythematosus nephritis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27936517 #FOAvip The discovery of serum biomarkers specific for paediatric lupus nephritis (pLN) will facilitate the non?invasive diagnosis, follow?up and more appropriate use of treatment. The aim of this study was to explore the role of serum high?mobility group box 1 (HMGB1) protein, antibodies against nucleosomes (anti?NCS), complement factor C1q (anti?C1q) and glomerular basement membrane (anti?GBM) in pLN. Serum samples of 42 patients with paediatric systemic lupus erythematosus (pSLE) (22 with pLN and 20 without renal involvement), 15 patients with other autoimmune nephritis (AN) and 26 healthy controls (HCs) were examined using enzyme?linked immunosorbent assay (ELISA). The activity of both pSLE and pLN was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) tool. The levels of all four biomarkers were significantly higher in pLN compared to AN and to HCs. The anti?NCS, anti?GBM and HMGB1 serum levels were significantly higher in pLN than in pSLE without renal involvement. The anti?C1q and the HMGB1 serum levels were correlated positively with pSLE activity. The HMGB1 serum levels were also correlated positively with pLN activity. These findings suggest that serum anti?NCS, anti?GBM and HMGB1 may serve as biomarkers specific for the presence of nephritis in pSLE. HMGB1 emerged as a useful biomarker for the assessment of pLN and pSLE activity, whereas anti?C1q only of pSLE activity. Twit Text FOAVip Novel biomarkers for the assessment of paediatric systemic lupus erythematosus nephritis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27936517 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27936517 #FOAvip English Wikipedia <ref>{{Cite pmid|27936517}}</ref> Novel biomarkers for the assessment of paediatric systemic lupus erythematosus nephritis #MMPMID27936517 Koutsonikoli A; Trachana M; Farmaki E; Tzimouli V; Pratsidou?Gertsi P; Printza N; Garyphallos A; Galanopoulou V; Kanakoudi?Tsakalidou F; Papachristou F Clin Exp Immunol 2017[Apr]; 188 (1): 79-85 PMID27936517show ga The discovery of serum biomarkers specific for paediatric lupus nephritis (pLN) will facilitate the non?invasive diagnosis, follow?up and more appropriate use of treatment. The aim of this study was to explore the role of serum high?mobility group box 1 (HMGB1) protein, antibodies against nucleosomes (anti?NCS), complement factor C1q (anti?C1q) and glomerular basement membrane (anti?GBM) in pLN. Serum samples of 42 patients with paediatric systemic lupus erythematosus (pSLE) (22 with pLN and 20 without renal involvement), 15 patients with other autoimmune nephritis (AN) and 26 healthy controls (HCs) were examined using enzyme?linked immunosorbent assay (ELISA). The activity of both pSLE and pLN was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) tool. The levels of all four biomarkers were significantly higher in pLN compared to AN and to HCs. The anti?NCS, anti?GBM and HMGB1 serum levels were significantly higher in pLN than in pSLE without renal involvement. The anti?C1q and the HMGB1 serum levels were correlated positively with pSLE activity. The HMGB1 serum levels were also correlated positively with pLN activity. These findings suggest that serum anti?NCS, anti?GBM and HMGB1 may serve as biomarkers specific for the presence of nephritis in pSLE. HMGB1 emerged as a useful biomarker for the assessment of pLN and pSLE activity, whereas anti?C1q only of pSLE activity. äNovel biomarkers for the assessment of paediatric systemic lupus eryth(epmc).pdf DeepDyve Pubget Overpricing