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10.1111/cei.12925 http://scihub22266oqcxt.onion/10.1111/cei.12925 C5343341!5343341!28076879     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2017 ; 188 (1): 174-81 Nephropedia Template TP {{tp|p=28076879|t=2017. Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis |pdf=|usr=}}{{28076879}} gab.com Text Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28076879 #FOAvip Anti?neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA?associated vasculitis (AAV). However, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious triggers may serve as inciting events for AAV disease activity. Antibodies of the immunoglobulin (Ig)M isotype often serve as markers of recent infection, and IgM ANCA have been identified previously in patients with AAV, although the frequency and clinical relevance of IgM ANCA is not well established. We sought to characterize IgM ANCA more clearly by creating a novel enzyme?linked immunosorbent assay (ELISA) for IgM antibodies to proteinase 3 [IgM proteinase 3 (PR3)?ANCA], which we applied to two large, clinically well?characterized trial cohorts of patients with granulomatosis with polyangiitis and microscopic polyangiitis. In the first cohort, IgM PR3?ANCA occurred with a frequency of 15·0%, and were associated with a higher degree of disease severity and a trend towards a higher rate of alveolar haemorrhage (29·6 versus 15·7%, P?=?0·10). Analysis of follow?up samples in this cohort showed that the presence of IgM PR3?ANCA was transient, but could recur. In the second cohort, IgM PR3?ANCA occurred with a frequency of 41·1%, and were also associated with a higher degree of disease severity. A higher rate of alveolar haemorrhage was observed among those with IgM PR3?ANCA (45·3 versus 15·8%; P?<?0·001). The association of transient IgM PR3?ANCA with an acute respiratory manifestation of AAV suggests a possible link between an infectious trigger and AAV disease activity. Twit Text FOAVip Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28076879 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28076879 #FOAvip English Wikipedia <ref>{{Cite pmid|28076879}}</ref> Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis #MMPMID28076879 Clain JM; Hummel AM; Stone JH; Fervenza FC; Hoffman GS; Kallenberg CGM; Langford CA; McCune WJ; Merkel PA; Monach PA; Seo P; Spiera RF; St Clair EW; Ytterberg SR; Specks U Clin Exp Immunol 2017[Apr]; 188 (1): 174-81 PMID28076879show ga Anti?neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA?associated vasculitis (AAV). However, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious triggers may serve as inciting events for AAV disease activity. Antibodies of the immunoglobulin (Ig)M isotype often serve as markers of recent infection, and IgM ANCA have been identified previously in patients with AAV, although the frequency and clinical relevance of IgM ANCA is not well established. We sought to characterize IgM ANCA more clearly by creating a novel enzyme?linked immunosorbent assay (ELISA) for IgM antibodies to proteinase 3 [IgM proteinase 3 (PR3)?ANCA], which we applied to two large, clinically well?characterized trial cohorts of patients with granulomatosis with polyangiitis and microscopic polyangiitis. In the first cohort, IgM PR3?ANCA occurred with a frequency of 15·0%, and were associated with a higher degree of disease severity and a trend towards a higher rate of alveolar haemorrhage (29·6 versus 15·7%, P?=?0·10). Analysis of follow?up samples in this cohort showed that the presence of IgM PR3?ANCA was transient, but could recur. In the second cohort, IgM PR3?ANCA occurred with a frequency of 41·1%, and were also associated with a higher degree of disease severity. A higher rate of alveolar haemorrhage was observed among those with IgM PR3?ANCA (45·3 versus 15·8%; P? äImmunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with(epmc).pdf DeepDyve Pubget Overpricing