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10.1016/j.cmet.2017.01.005 http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.01.005 C5342930!5342930 !28190773     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28190773 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Metab 2017 ; 25 (3 ): 727-738 Nephropedia Template TP {{tp|p=28190773 |t=2017. ? Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice |pdf=|usr=}}{{28190773 }} gab.com Text Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28190773 #FOAvip Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of ? cells. How ? cells respond to immune attack is unknown. We identified a population of ? cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal ? cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cells. There is reduced expression of ? cell identity genes and diabetes antigens and increased immune inhibitory markers and stemness genes. This new subpopulation is resistant to killing when diabetes is precipitated with cyclophosphamide. Human ? cells show similar changes when cultured with immune cells. These changes may account for the chronicity of the disease and the long-term survival of ? cells in some patients. Twit Text FOAVip Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28190773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28190773 #FOAvip English Wikipedia <ref>{{Cite pmid|28190773 }}</ref> ? Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice #MMPMID28190773 Rui J ; Deng S ; Arazi A ; Perdigoto AL ; Liu Z ; Herold KC Cell Metab 2017[Mar]; 25 (3 ): 727-738 PMID28190773 show ga Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of ? cells. How ? cells respond to immune attack is unknown. We identified a population of ? cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal ? cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cells. There is reduced expression of ? cell identity genes and diabetes antigens and increased immune inhibitory markers and stemness genes. This new subpopulation is resistant to killing when diabetes is precipitated with cyclophosphamide. Human ? cells show similar changes when cultured with immune cells. These changes may account for the chronicity of the disease and the long-term survival of ? cells in some patients. |*Disease Progression [MESH] |Animals [MESH] |Antibodies, Monoclonal/pharmacology [MESH] |CD3 Complex/metabolism [MESH] |Cell Survival/drug effects/immunology [MESH] |Cells, Cultured [MESH] |Diabetes Mellitus, Type 1/*immunology/*pathology [MESH] |Female [MESH] |Humans [MESH] |Immunotherapy [MESH] |Insulin-Secreting Cells/drug effects/*immunology/*pathology [MESH] |Lymphocytes/drug effects/pathology [MESH] |Mice, Inbred NOD [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Sequence Analysis, RNA [MESH] |Transcription, Genetic/drug effects [MESH]? Cells that Resist Immunological Attack Develop during Progression of(epmc).pdf DeepDyve Pubget Overpricing