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10.1016/bs.acr.2016.07.002 http://scihub22266oqcxt.onion/10.1016/bs.acr.2016.07.002 C5342905!5342905!27613129     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Cancer+Res 2016 ; 132 (ä): 45-71 Nephropedia Template TP {{tp|p=27613129|t=2016. The Relationship Between Dormant Cancer Cells and Their Microenvironment |pdf=|usr=}}{{27613129}} gab.com Text The Relationship Between Dormant Cancer Cells and Their Microenvironment JO: Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27613129 #FOAvip The majority of cancer deaths are due to metastases that can occur years or decades after primary tumor diagnosis and treatment. Disseminated tumor cells (DTCs) surviving in a dormant state in target organs appear to explain the timing of this phenomenon. Knowledge on this process is important as it might provide a window of opportunity to prevent recurrences by eradicating dormant DTCs and/or by maintaining DTCs in a dormant state. Importantly, this research might offer markers of dormancy for early monitoring of metastatic relapse. However, our understanding of the mechanisms underlying the regulation of entry into and exit from dormancy is still limited and crippling any therapeutic opportunity. While cancer cell-intrinsic signaling pathways have been linked to dormancy regulation, it is likely that these pathways and the switch controlling reactivation from dormancy are regulated by microenvironmental cues. Here we review and discuss recent findings on how the microenvironment regulates cancer dormancy and raise new questions that may help advance the field. Twit Text FOAVip The Relationship Between Dormant Cancer Cells and Their Microenvironment ????Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27613129 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27613129 #FOAvip English Wikipedia <ref>{{Cite pmid|27613129}}</ref> The Relationship Between Dormant Cancer Cells and Their Microenvironment #MMPMID27613129 Linde N; Fluegen G; Aguirre-Ghiso J Adv Cancer Res 2016[]; 132 (ä): 45-71 PMID27613129show ga The majority of cancer deaths are due to metastases that can occur years or decades after primary tumor diagnosis and treatment. Disseminated tumor cells (DTCs) surviving in a dormant state in target organs appear to explain the timing of this phenomenon. Knowledge on this process is important as it might provide a window of opportunity to prevent recurrences by eradicating dormant DTCs and/or by maintaining DTCs in a dormant state. Importantly, this research might offer markers of dormancy for early monitoring of metastatic relapse. However, our understanding of the mechanisms underlying the regulation of entry into and exit from dormancy is still limited and crippling any therapeutic opportunity. While cancer cell-intrinsic signaling pathways have been linked to dormancy regulation, it is likely that these pathways and the switch controlling reactivation from dormancy are regulated by microenvironmental cues. Here we review and discuss recent findings on how the microenvironment regulates cancer dormancy and raise new questions that may help advance the field. äThe Relationship Between Dormant Cancer Cells and Their Microenvironme(epmc).pdf DeepDyve Pubget Overpricing